Bulletin of the Korean Chemical Society

Korean Chemical Society (대한화학회)
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Some of the Food Color Additives Are Potent Inhibitors of Human Protein Tyrosine Phosphatases

  • Shrestha, Suja (Department of Chemistry and Institute of Molecular Cell Biology, Inha University) ;
  • Bhattarai, Bharat Raj (Department of Chemistry and Institute of Molecular Cell Biology, Inha University) ;
  • Lee, Keun-Hyeung (Department of Chemistry and Institute of Molecular Cell Biology, Inha University) ;
  • Cho, Hyeong-Jin (Department of Chemistry and Institute of Molecular Cell Biology, Inha University)
  • Published : 2006.10.20
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Abstract

Synthetic color additives approved for general food use are sixteen in European Union, seven in U. S. A. and twelve in Japan. Twelve food dyes were examined for their inhibitory potency against human protein tyrosine phosphatases (PTPases). Half of the food colorants inhibited PTPases significantly and three of them were potent inhibitors with low micromolar IC50 values. Also examined were the synthetic dyes structurally similar but not allowed in food. Some of them were potent inhibitors of PTPases. Considering the importance of PTPases in cellular signal transduction, inhibition of PTPases by food colorants might cause harmful effects in human health.

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