Korean Journal of Biological Psychiatry (생물정신의학)
- Volume 12 Issue 2
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- Pages.123-135
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- 2005
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- 1225-8709(pISSN)
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- 2005-7571(eISSN)
The Differences of EEG Coherence between Schizophrenia and Bipolar Disorder
정신분열병과 양극성장애에서 뇌파 동시성의 비교분석
- Kim, Yong-Kyu (Yong-In Mental Hospital) ;
- Shin, Jae-Kong (Kyunggi Provincial Hospital For The Elderly) ;
- Park, Chong-Won (Yong-In Mental Hospital) ;
- Hong, Kyung Sue (Department of Psychiatry, Sungkyunkwan University School of Medicine, Samsung Seoul Hospital) ;
- Lee, Seung-Yeoun (Department of Applied Mathematics, Sejong University) ;
- Oh, Hong-Seok (Yong-In Mental Hospital) ;
- Lee, Yong-Suk (Yong-In Mental Hospital) ;
- Kwak, Yong-Tae (Hyoja Geriatric Hospital) ;
- Chang, Jae Seung (Department of Neuropsychiatry and Clinical Research Institute, Seoul National University Hospital) ;
- Lee, Yu-Sang (Yong-In Mental Hospital)
- 김용규 (용인정신병원) ;
- 신재공 (경기도립 노인병원) ;
- 박종원 (용인정신병원) ;
- 홍경수 (성균관대학교 의과대학 삼성서울병원 정신과학교실) ;
- 이승연 (세종대학교 응용수학과) ;
- 오홍석 (용인정신병원) ;
- 이용석 (용인정신병원) ;
- 곽용태 (효자병원) ;
- 장재승 (서울대학교병원 신경정신과, 임상의학연구소) ;
- 이유상 (용인정신병원)
- Published : 2005.11.30
Abstract
Objectives:EEG coherence could imply the connectivity between two different areas of the brain, which is known to be important in the pathophysiology of bipolar I disorder(BPD I) and schizophrenia. The authors investigated EEG coherence in patients with BPD I and schizophrenia to examine the connectivity of the neural circuit. Methods:EEGs were recorded in 15 schizophrenia and 14 bipolar disorder patients, and 14 age-matched normal control subjects from 16 electrodes with linked-ear reference. Spectral parameters and coherence were calculated for the alpha bandwidth(8-13Hz) by a multi-channel autoregressive model using 20 artifact-free 2-seconds epochs and the differences were compared among three groups by two different statistical methods;F-test and Kruskal-Wallis test. Furthermore, when there were significant differences among three groups, Scheffe's multiple comparison tests were provided and Jonckheere-Terpstra tests for the ordered alternative were given. Results:In the intra-hemispheric comparison, left frontal coherence was increased in order of control, BPD I and schizophrenia. In the inter-hemispheric comparison, 1) inter-prefrontal coherence in BPD I was signifi- cantly higher than in normal controls, and 2) inter-prefrontal coherence in schizophrenia was significantly lower than in controls. Conclusion:These results suggest that 1) both schizophrenia and BPD I are diseases having the abnormality of neural circuit connectivity in both frontal and prefrontal lobes, and 2) the abnormality is more severe in schizophrenia than in BPD I. Furthermore, the data support that a common pathogenetic process may reside in both schizophrenia and BPD I.