Korean Journal of Biological Psychiatry (생물정신의학)
- Volume 12 Issue 2
- /
- Pages.114-122
- /
- 2005
- /
- 1225-8709(pISSN)
- /
- 2005-7571(eISSN)
Serum Homocysteine Level and MTHFR C677T, A1298C Gene Polymorphism in Korean Schizophrenics
정신분열병 환자에서의 혈중 Homocysteine 농도와 MTHFR C677T, A1298C의 유전자 다형성
-
Lee, Young Sik
(Department of Psychiatry, Chung-Ang University, College of Medicine) ;
- Jeon, Chang Moo (Department of Psychiatry, Chung-Ang University, College of Medicine) ;
- Na, Chul (Department of Psychiatry, Chung-Ang University, College of Medicine) ;
- Chae, Seok Lae (Department of Labaratory Medicine, Chung-Ang University, College of Medicine)
-
이영식
(중앙대학교 의과대학 신경정신과학교실) ;
- 전창무 (중앙대학교 의과대학 신경정신과학교실) ;
- 나철 (중앙대학교 의과대학 신경정신과학교실) ;
- 채석래 (중앙대학교 의과대학 진단검사의학교실)
- Published : 2005.11.30
Abstract
Objectives:Recently in schizophrenia high incidence of MTHFR(methylenetetrahydrofolate reductase), which is a main relating enzyme that reduce homocysteine level, genetic variations were reported. So we examined serum homocysteine level and MTHFR gene polymorphism in Korean schizophrenics. Method:We compared serum homocysteine level and MTHFR polymorphism between 235 schizophrenics (100male, 135female) and 235 normal controls(100male, 135female). C677T and A1298C polymorphism of MTHFR gene were analyzed. Results:1) C677T genetic mutation(CT and TT) were more frequent in schizophrenia group than normal control group(p<0.01). But the difference of A1298C mutation frequency was not found between two groups. 2) In schizophrenia patients, TT genotype of C677T mutation showed significantly higher homocysteine level (29.99uM/L) than other group(CT:13.34uM/L, CC:9.34uM/L p<0.01). 3) MTHFR 677 TT homogeneous mutation genotype showed two times more risk(odds ratio=2.15) than 677CC normal genotype in schizophrenia. Conclusion:Some schizophrenia patients with high homocysteine serum level may have C677T TT genotype. In that case, folate ingestion could be a good management for clinical improvement.