Korean Journal of Biological Psychiatry (생물정신의학)

The Korean Society of Biological Psychiatry (대한생물정신의학회)
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The CDH2 Gene Polymorphism in Schizophrenia

정신분열병의 CDH2 유전자 다형성

  • Lee, Won Seok (Seoul National Mental Hospital) ;
  • Kim, Mi Kyung (Seoul National Mental Hospital) ;
  • Jung, Han Yong (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital) ;
  • Woo, Sung Il (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital) ;
  • Kwon, Young Joon (Department of Psychiatry, College of Medicine, Soonchunhyang University Hospital) ;
  • Kim, Jong Woo (Department of Neuropsychiatry, College of Medicine, Kyunghee University Hospital) ;
  • Lee, Hee Je (Department of Pharmacology, College of Medicine, Kangwon University Hospital)
  • 이원석 (국립서울병원) ;
  • 김미경 (국립서울병원) ;
  • 정한용 (순천향대학교 의과대학 정신과학교실) ;
  • 우성일 (순천향대학교 의과대학 정신과학교실) ;
  • 권영준 (순천향대학교 의과대학 정신과학교실) ;
  • 김종우 (경희대학교 의과대학 신경정신과학교실) ;
  • 이희제 (강원대학교 의과대학 약리학교실)
  • Published : 2005.05.31
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Abstract

Objective:There has been increasing evidence that neurodevelopmental dysfunction is involved in the pathophysiology of schizophrenia. Cadherin is known to be one of the important molecules in neurodevelopment. This study was performed to examine the relationship between T816C polymorphism of CDH2 gene and schizophrenia. Methods:Genoytypes of T816C polymorphism of CDH2 gene were analyzed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) in 156 Korea patents with schizophrenia and 170 controls. Results:No difference was found between the patients with schizophrenia and the controls in genotype and allele frequencies of T816C polymorphism of CDH2 gene. Conclusion:The results of this study do not support an association between T816C polymorphism of CDH2 gene and schizophrenia. However, it is necessary to investigate other polymorphic regions of CDH2 in schizophrenia.

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