Journal of Animal Science and Technology

Korean Society of Animal Sciences and Technology (한국축산학회)
권호 표지
DOI QR코드

DOI QR Code

Influence of Dietary Conjugated Linoleic Acid on Growth Performance and Body Fat Metabolism in Broiler Chickens

사료내 Conjugated Linoleic Acid 첨가가 육계의 성장 및 체지방 대사에 미치는 영향

  • Ko, Y.H. (Department of Animal Science & Biotechnology, RAIRC, Jinju National University) ;
  • Yang, H.Y. (Department of Animal Science & Biotechnology, RAIRC, Jinju National University) ;
  • Kang, S.Y. (Department of Animal Science & Biotechnology, RAIRC, Jinju National University) ;
  • Jang, In-Surk (Department of Animal Science & Biotechnology, RAIRC, Jinju National University)
  • 고영현 (국립 진주산업대학교 동물생명과학과.동물생명산업지역협력연구센터(RAIRC)) ;
  • 양혜영 (국립 진주산업대학교 동물생명과학과.동물생명산업지역협력연구센터(RAIRC)) ;
  • 강선영 (국립 진주산업대학교 동물생명과학과.동물생명산업지역협력연구센터(RAIRC)) ;
  • 장인석 (국립 진주산업대학교 동물생명과학과.동물생명산업지역협력연구센터(RAIRC))
  • Published : 2005.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

The current study was conducted to investigate the effects of dietary conjugated linoleic acid(CLA) on growth performance and body fat metabolism in broiler chickens. A total of 48 male birds aged 3 days were randomly allotted into three dietary groups; CORN(com oil 1.5%), CLA I (com oil 0.75 %+ CLA 0.75 %) and CLA II(CLA 1.5%) groups. After feeding commercial diet ad libitum for 3 weeks, eight selected birds on the basis of body weight were housed, two birds in a cage, and continuously given ad libitum corresponding experimental diet for another 2 weeks. As a result, dietary addition of CLA did not influence on body weight, gain and feed conversion rote. The relative weights of the liver and deposited fats(abdominal and thigh fat' pads) were not also affected by the dietary treatments. Serum glucose, triglyceride and cholesterol levels markedly( P < 0.05) decreased in CLA II compared with those in CORN group. However, serum nonesterified fatty acid(NEFA) was not altered by dietary CLA. Serum leptin level was tended to be decreased by dietary CLA without statistical difference. The diet supplemented with CLA caused a significant(P< 0.05) decrease in hepatic total lipid and NEFA without changing triglyceride level. Also, feeding dietary CLA at the level of 1.5% reduced leptin mRNA expression in the liver and abdominal fats compared with feeding com oil, In conclusion, our results suggest that dietary 1.5% CLA may affect, at least in part, lipid metabolism in the liver of broiler chickens.

Keywords

References

  1. Ahn, D. C., Sell, J. L., Jo, C., Chamruspollert, M. and Jeffrey, M. 1999. Effect of dietary conjugated linoleic acid on the quality characteristics of chicken eggs during refrigerated storage. Poul. Sci. 78: 922-928
  2. An, B. K., Shin, K. H., Kobayashi, Y., Tanaka, K. and Kang, C. W. 2003. Excessive dietary conjugated linoleic acid affects hepatic lipid contents and nusclular fatty acid composition in young chicks. Asian-Aust. J. Anim. Sci. 16(8):1171-1176
  3. Ashwell, C. M., Czerwinski, S. M., Brocht, D. M. and McMurtry, J. P. 1999. Hormonal regulation of leptin expression in broiler chickens. Am. J Physiol. 276(1 Pt 2):R226-232
  4. Badinga, L., Selberg, K. T., Dinges, A. C., Corner, C. W. and Miles, R. D. 2003. Dietary conjugated linoleic acid alters hepatic lipid content and fatty acid composition in broiler chickens. Poult Sci. 82(1):111-116
  5. Belury, M. A. 2002. Inhibition of carcinogenesis by conjugated linoleic acid: potential mechanisms of action. J. Nutr. 132(10):2995-2998
  6. Caro, J. F., Sinha, M. K., Molaczynski, J. W., Zhang, P. L. and Considine, R. V. 1996. Leptin: the tale of an obesity gene. Diabetes 45:1455-1462
  7. Cherian, G., Goeger, M. P. and Ahn, D. U. 2002. Dietary conjugated linoleic acid with fish oil alters yolk n-3 and trans fatty acid content and volatile compounds in raw, cooked and irradiated eggs. Poult. Sci. 81(10):1571-1577
  8. Delany, J. P., Blohm, F., Truett, A. A., Scimeca, J. A. and West, D. B. 1999. Conjugated linoleic acid rapidly reduces body fat content in mice without affecting energy intake. Comp. Physiol. 45:R1172-1179
  9. Dridi, S., Williams, J., Bruggeman, V., Onagbesan, M., Raver, N., Decuypere, E., Djiane, J., Gertler, A. and Taouis, M. A. 2000. Chicken leptin-specific radioimmunoassay. Domest. Anim. Endocrinol. 18(3): 325-335 https://doi.org/10.1016/S0739-7240(00)00053-9
  10. Du, M., Ahn, D. U., Nam, K. C. and Sell, J. L. 2001. Volatile profiles and lipid oxidation of irradiated cooked chicken meat from laying hens fed diets containing conjugated linoleic acid. Poult. Sci. 80(2):235-241
  11. Evans, K., Burdge, G. C., Wootton, S. A., Clark, M. L. and Frayn, K. N. 2002. Regulation of dietary fatty acid entrapment in subcutaneous adipose tissue and skeletal muscle. Diabetes, 51(9):2684- 2690 https://doi.org/10.2337/diabetes.51.9.2684
  12. Folch, J., Lees, M. and Sloane-Stanley, G. H. 1957. A simple method for the isolation and purification of total lipid form animal tissues. J. Biol. Chem. 226:497
  13. Ha, Y. L., Grimm, N. K. and Pariza, M. W. 1987. Anticarcinogens from fried ground beef : heat-altered derivatives of linoleic acid. Carcinogenesis, 8(12):1881-1887 https://doi.org/10.1093/carcin/8.12.1881
  14. Ha, Y. L., Grimm, N. K. and Pariza, M. W. 1989. Newly recognized anticarcinogenic fatty acids: identification and quantification in natural and processed cheeses. J. Agric. Food Chem. 37(1):75-81 https://doi.org/10.1021/jf00085a018
  15. Ha, Y. L., Ha, H. S., Ha, J., Kim, Bahn, K. N., Lee, E. J. and Ha, J. K. 1994. Effects of dietary conjugated dienoic isomers of linoleic acid(CLA) on cholesterol and CLA contents of hen's egg. In 1994 IFT Annual Meeting Technical Program, 79D 6, p. 249
  16. Haumann, B. F. 1996. Conjugated linoleic acid offers research promise. INFORM, 7(2):152-159
  17. Houseknecht, K. L., Vanden, H. J. P., Moya- Camarena, S. Y., Portocarrero, C. P., Peck, L. W., Nickel, K. P. and Belury, M. A. 1998. Dietary conjugated linoleic acid normalizes impaired glucose tolerance in the Zucker diabetic fatty(fa/fa) rat. Biochem. Biophys. Res. Commun. 244:678-682 https://doi.org/10.1006/bbrc.1998.8303
  18. Hughes, P. E, Hunter, W. J. and Tove, S. B. 1982. Biohydrogenation of unsaturated fatty acids. Purification and properties of cis-9, trans-11-octadecadienoate reductase. J. Biol. Chem. 257(7):3643- 3649
  19. Jones, S., Ma, D. W., Robinson, F. E., Field, C. J. and Clandinin, M. T. 2000. Isomers of conjugated linoleic acid (CLA) are incorporated into egg yolk lipids by CLA-fed laying hens. J. Nutr. 130: 2002-2005
  20. Kang, K. and Pariza, M. W. 2001. trans-10,cis-12- Conjugated linoleic acid reduces leptin secretion from 3T3-L1 adipocytes. Biochem. Biophys. Res. Com. 287:377-382 https://doi.org/10.1006/bbrc.2001.5603
  21. Lee, K. N., Kritchevsky, D. and Pariza, M. W. 1994. Conjugated linoleic acid and atherosclerosis in rabbits. Atherosclerosis, 108:19-25 https://doi.org/10.1016/0021-9150(94)90034-5
  22. Park, Y., Albright, K. J., Liu, W., Storkson, J. M., Cook, M. E. and Pariza, M. W. 1997. Effect of conjugated linoleic acid on body composition in mice. Lipids, 32:853-858 https://doi.org/10.1007/s11745-997-0109-x
  23. Park, Y., Storkson, J. M., Albright, K. J., Liu, W. and Pariza, M. W. 1999. Evidence that the trans- 10, cis-12 isomer of conjugated linoleic acid induces body composition changes in mice. Lipids, 34(3):235-241 https://doi.org/10.1007/s11745-999-0358-8
  24. Rahman, S. M., Wang, Y., Yotsumoto, H., Cha, J., Han, S., Inoue, S. and Yanagita, T. 2001. Effects of conjugated linoleic acid on serum leptin concentration, body-fat accumulation, and beta-oxidation of fatty acid in OLETF rats. Nutrition, 17(5):385-390 https://doi.org/10.1016/S0899-9007(00)00584-0
  25. SAS. 1996. User's Guide: Statistics Version 6.12 Edition. SAS inst, Inc., Cary., NC
  26. Sell, J. L., Jin, S. and Jeffrey, M. 2001. Meta- bolizable energy value of CLA for broiler chicks and laying hens. Poult. Sci. 80(2):209-214
  27. Stangl, G. I., Muller, H. and Kirchgessner, M. 1999. Conjugated linoleic acid effects on circulating hormones, metabolites and lipoproteins, and its proportion in fasting serum and erythrocyte membranes of swine. Eur. J. Nutr. 38(6):271-277 https://doi.org/10.1007/s003940050077
  28. Szymczyk, B., Pisulewski, P. M., Szczurek, W. and Hanczakowski, P. 2001. Effects of conjugated linoleic acid on growth performance, feed conversion efficiency, and subsequent carcass quality in broiler chickens. Br. J. Nutr. 85(4):465-473 https://doi.org/10.1079/BJN2000293
  29. Takahashi, K., Kawamata, K., Akiba, Y., Iwata, T. and Kasai, M. 2002. Influence of dietary conjugated linoleic acid isomers on early inflammatory responses in male broiler chickens. Br. Poult. Sci. 43(1):47-53
  30. Tischendorf, F., Mockel, P., Schone, F., Plonne, M. and Jahreis, G. 2002. Effect of dietary conjugated linoleic acids on the distribution of fatty acids in serum lipoprotein fractions and different tissues of growing pigs. J. Anim. Physiol. Nutr(Berl). 86(9- 10):313-325 https://doi.org/10.1046/j.1439-0396.2002.00385.x
  31. Tsuboyama-Kasaoka, N., Takahashi, M., Tanemura, K., Kim, H. J., Tange, T., Okuyama, H., Kasai, M., Ikemoto, S. and Ezaki, O. 2000. Conjugated linoleic acid supplementation reduces adipose tissue by apoptosis and develops lipodystrophy in mice. Diabetes, 49:1534-1542 https://doi.org/10.2337/diabetes.49.9.1534