Journal of the korean academy of Pediatric Dentistry (대한소아치과학회지)
- Volume 32 Issue 3
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- Pages.517-524
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- 2005
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- 1226-8496(pISSN)
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- 2288-3819(eISSN)
A COMPARISON OF THE SEDATIVE EFFECT ON CHLORAL HYDRATE DOSAGE IN THE SEDATION OF THE PEDIATRIC DENTAL PATIENTS
소아환자 진정요법에서 chloral hydrate의 용량에 따른 진정효과에 관한 연구
- Rho, Seung-Chul (Department of Pediatric Dentistry and Dental Research Institute, College of Dentistry, Seoul National University) ;
- Kim, Young-Jae (Department of Pediatric Dentistry and Dental Research Institute, College of Dentistry, Seoul National University) ;
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Jang, Ki-Taeg
(Department of Pediatric Dentistry and Dental Research Institute, College of Dentistry, Seoul National University) ;
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Hahn, Se-Hyun
(Department of Pediatric Dentistry and Dental Research Institute, College of Dentistry, Seoul National University)
- 노승철 (서울대학교 치과대학 소아치과학교실) ;
- 김영재 (서울대학교 치과대학 소아치과학교실) ;
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장기택
(서울대학교 치과대학 소아치과학교실) ;
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한세현
(서울대학교 치과대학 소아치과학교실)
- Published : 2005.08.31
Abstract
Despite the widespread use of chloral hydrate with hydroxyzine in the sedation of children, there is little agreement among pediatric dentists regarding its therapeutic dosage for the management of very uncooperative young children. Also, increasing concern has been raised with respect to its frequent failure to provide adequate levels of sedation when used according to the manufacturer's recommended dosage. Therefore, there has been many suggestions with respect to sedative effectiveness and safety of varying drug dosage, and some pediatric dental articles have advocated dosages exceeding manufacturer's recommendations. This study was performed to compare the effectiveness and safety in behavior management of the manufacturer's recommended dose of chloral hydrate(50mg/kg) with those of a higher dose(70mg/kg) used together with hydroxyzine(2mg/kg) and nitrous oxide(50%) when young children were sedated for dental treatment. The following results were obtained; 1. II group(70mg/kg) displayed higher mean score compared to I group(50mg/kg) with regard to the degree of sleep, crying, movement and overall behavior. The difference was statistically significant(p<0.05). 2. In comparison of success rates for sedation between the two groups, I group and II group showed 38.7% and 71.0% success rates respectively. An analysis of variance was statistically significant(p<0.05). 3. Comparing the occurrence rate hypoxia between the two groups, there were 22.6% and 19.4% occurrence of hypoxia in I group and II group. An analysis of variance was not statistically significant(p>0.05).
Chloral hydrate는 소아환자 진정요법 시 hydroxyzine과 함께 가장 일반적으로 사용되는 약물임에도 불구하고 협조도가 불량한 어린 환아들의 행동조절을 위한 적절한 용량에 대한 의견이 분분한 실정이며, 또한 chloral hydrate를 제조사의 추천 용량으로 사용 시 적절한 진정수준을 제공하는데 있어 잦은 실패를 초래하는 경우를 볼 수 있었다. 지금까지도, chloral hydrate를 사용함에 있어 약물의 용량에 따른 진정의 효과와 안전성 측면에서 많은 의견들이 존재한다. 본 연구는 소아환자 진정요법에서 chloral hydrate의 용량에 따른 진정의 효과와 안전성 측면에서 적절한 용량을 제시하고자, 소아환자 진정요법 시 제조사의 추천용량인 chloral hydrate 50mg/kg와 더 높은 용량인 70mg/kg을 hydroxyzine 2mg/kg와 50%
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