Korea-Australia Rheology Journal

  • 제17권1호
  • /
  • Pages.15-20
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  • 2005
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  • 1226-119X(pISSN)
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  • 2093-7660(eISSN)
한국유변학회 (The Korean Society of Rheology)
권호 표지

Relationship between morphology and viscosity of the main culture broth of Cephalosporium acremonium M25

  • Kim Jong Chae (Department of Chemical and Biological Engineering, Korea University) ;
  • Lim Jung Soo (Department of Chemical and Biological Engineering, Korea University) ;
  • Kim Jung Mo (Department of Chemical and Biological Engineering, Korea University) ;
  • Kim Chongyoup (Department of Chemical and Biological Engineering, Korea University) ;
  • Kim Seung Wook (Department of Chemical and Biological Engineering, Korea University)
  • 발행 : 2005.03.01
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초록

In this study, the relationship between morphology and viscosity of the main culture broth of Cephalosporium acremonium M25 was investigated in a 2.5 L bioreactor. The differentiation of C. acremonium M25 showed a complex pattern during the main culture. The morphological changes of C. acremonium M25 were related to the rheological properties of the culture broth and it was well agreed with the power law model. As a result of rheology study, it was found that rheological properties of the main culture broths of C. acremonium M25 in bioreactor were closely related to morphological changes. Also, fractal dimension fairly predicted morphological and rheological changes in the main culture broth.

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참고문헌

  1. Cruz, A. J. G., A. S. Silva, M. L. G. C. Araujo, R.C. Giordano and C. O. Hokka, 1999, Modeling and optimization of the cephalosporin C production bioprocess in a fed batch bioreactor with invert sugar as substrate, Chem. Eng. Sci. 54, 3137 https://doi.org/10.1016/S0009-2509(98)00364-9
  2. Kim, B. M., S. W. Kim and D. R. Yang, 2003, Cybernetic modeling of the cephalosporin C fermentation process by Cephalosporium acremonium, Biotechnol. Lett. 25, 611 https://doi.org/10.1023/A:1023080027754
  3. Lee, M. S., J. S. Lim, C. H. Kim, K. K. Oh, D. R. Yang and S. W. Kim, 2001a, Enhancement of Cephalosporin C production by cultivation of Cephalosporium acremonium M25 using a mixture of inocula, Letters in Appl. Microbiol. 32, 402 https://doi.org/10.1046/j.1472-765X.2001.00931.x
  4. Lee, M. S., J. S. Lim, C. H. Kim, K. K. Oh, S. I. Hong and S. W. Kim, 2001b, Effects of nutrients and culture conditions on morphology in the seed culture of Cephalosporium acremonium ATCC 20339, Biotechnol. Bioprocess Eng. 6, 156 https://doi.org/10.1007/BF02931963
  5. Lim, J. S., J. H. Kim, C. Y. Kim and S. W. Kim, 2002, Morphological and rheological properties of culture broth of Cephalosporium acremonium M25, Kor.-Aus. Rheology J. 14, 11
  6. Obert, M., P. Pfeifer and M. Sernetz, 1990, Microbial growth patterns described by fractal geometry, J. Bacteriol. 172, 1180 https://doi.org/10.1128/jb.172.3.1180-1185.1990
  7. Riely, G. L., K. G. Tucker and C. R. Thomas, 2000, Effect of biomass concentration and mycelial morphology on fermentation broth rheology, Biotechnol. Bioeng. 68, 160 https://doi.org/10.1002/(SICI)1097-0290(20000420)68:2<160::AID-BIT5>3.0.CO;2-P
  8. Ryoo, D.H., 1999, Fungal fractal morphology of pellet formation in Aspergillus niger, Biotechnol. Tech. 13, 33 https://doi.org/10.1023/A:1008835529941
  9. Sinha, J., J. T. Bae, J. P. Park, C. H. Song and J. W. Yun, 2001, Effect of substrate concentration on broth rheology and fungal morphology during exo-biopolymer production by Paecilomyces japonica in a batch bioreactor, Enzyme Microb. Technol. 29, 392 https://doi.org/10.1016/S0141-0229(01)00418-5
  10. Vicik, S. M., A. J. Fedor and R. W. Swartz, 1990, Defining an optimum carbon source/methionine feed strategy for growth and cephalosporin C formation by Cephalosporium acremonium, Biotechnol. Prog. 6, 333 https://doi.org/10.1021/bp00005a004