Korean Journal of Veterinary Service (한국동물위생학회지)

The Korean Society of Veterinary Service (한국동물위생학회)
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Ethylene glycol intoxication in German shepherd dogs

세퍼드에서 ethylene glycol 독성에 관한 연구

  • Park Hyun-Jong (Bio-Safety Research Institute, Chonbuk National University) ;
  • Lee Oh-Hyung (Bio-Safety Research Institute, Chonbuk National University) ;
  • Lim Chae Woong (Bio-Safety Research Institute, Chonbuk National University)
  • 박현종 (전북대학교 생체안전성 연구소) ;
  • 이오형 (전북대학교 생체안전성 연구소) ;
  • 임채웅 (전북대학교 생체안전성 연구소)
  • Published : 2005.03.01
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Abstract

Ethylene glycol (EG) intoxication in dogs can pose a diagnostic challenge. We investigated the effect of a lethal dose of EG to the Shepherd on blood, urine test, and histopathologic observation. Shepherds were treated orally with EG at $10\;m{\ell}/kg$ body weight. Clinically, EG caused the vomition, depression of central brain. Anion gap was increased, which was decreased pH of blood, The blood osmorality was increased at 3 hours, and BUN and creatinine was increased at 24 hour significantly. The pH of urine decreased. The crystal of calcium oxalate appeared at 6 hours. The amount of crystals increased at 12 and 24 hours. Microscopically, the degeneration of proximal tubules were shown at 1 hour and finally progressed as acute tubular nephrosis at 24 hours. These results suggest that the blood and urine test accompanied with histopathological examination be helpful to investigate the EG intoxication.

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References

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