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The Pharmaceutical Society of Korea (대한약학회)
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Butyrylcholinesterase Inhibitory Guaianolides from Amberboa ramosa

  • Khan Sher Bahadar (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Haq Azhar-ul (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Perveen Shagufta (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Afza Nighat (Pharmaceutical Research Centre, PCSIR Labs Complex Karachi) ;
  • Malik Abdul (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Nawaz Sarfraz Ahmad (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Shah Muhammad Raza (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi) ;
  • Choudhary Muhammad lqbal (International Centre for Chemical Sciences, H.E.J. Research Institute of Chemistry, University of Karachi)
  • Published : 2005.02.01
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Abstract

Phytochemical investigation of the whole plant of Amberboa ramosa led to the isolation of six sesquiterpene lactones which could be identified as $8{\alpha}$-hydroxy-$11{\beta}$-methyl-$1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H,\;11{\alpha}H-guai-10(14)$, 4(15)-dien-6, 12-olide(2), $3{\beta},\;8{\alpha}-dihydroxy-11{\alpha}-methyl-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H,\;11{\beta}H-guai-10(14)$, 4(15)-dien-6, 12-olide (2), $3{\beta},\;4{\alpha},\;8{\alpha}-trihydroxy-4{\beta}(hydroxymethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide (3), $3{\beta},\;4{\alpha},\;8{\alpha}-trihydroxy-4{\beta}-(chloromethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide(4), $3{\beta},\;4{\alpha},\;dihydroxy-4{\beta}-(hydroxymethyl)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide(5), $3{\beta},\;4{\alpha}-dihydroxy-4{\beta}-(chloromethyl)-8{\alpha}-(4-hydroxymethacrylate)-1{\alpha}H,\;5{\alpha}H,\;6{\beta}H,\;7{\alpha}H-guai-10(14)$, 11(13)-dien-6, 12-olide (6) by spectroscopic methods. All of them showed inhibitory potential against butyrylcholinesterase.

Keywords

References

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