KOREAN JOURNAL OF CROP SCIENCE (한국작물학회지)

The Korean Society of Crop Science (한국작물학회)
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ent-Kaurane- and ent-Pimarane-Type Diterpenoids from Siegesbeckia pubescens and Their Cytotoxicity in Caki Cells

  • Lee Sanghyun (Biohealth Products Research Center, Inje University) ;
  • Noh Eun Jung (Natural Products Research Institute, Seoul National University) ;
  • Kim Jung Sook (Biohealth Products Research Center, Inje University) ;
  • Son Eun Mi (Biohealth Products Research Center, Inje University) ;
  • Pan Xu (Biohealth Products Research Center, Inje University) ;
  • Kim Yeong Shik (Natural Products Research Institute, Seoul National University) ;
  • Kim Bak-Kwang (College of Pharmacy, Seoul National University) ;
  • Lee Burm-Jong (Biohealth Products Research Center, Inje University)
  • Published : 2005.06.01
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Abstract

ent-Kaurane- and ent-pimarane-type diterpenoids were isolated from the methanol extract of Siegesbeckia pubescens by column chromatography. Their structures were elucidated as ent-16$\alpha$H,17-hydroxy-kau­ran-19-oic acid (1), ent-4,17-dihydroxy-16$\alpha$-methyl-kau­ran-19-oic acid (2), ent-16$\beta$,17-dihydroxy-kauran-19-oic acid (3), kirenol (4) and ent-16$\beta$,17,18-trihydroxy-kauran­19-oic acid (5) by spectral analysis. The cytotoxicity of these compounds in Caki cells was assayed by a cell counting kit. Only one group treated with kirenol (4), an entpimarane-type diterpenoid, showed the inhibition of the cell growth in Caki cells.

Keywords

References

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