A Case of Passive Smoking Induced Respiratory Bronchiolitis Associated Interstitial Lung Disease

간접흡연으로 유발된 호흡 세기관지염 연관 간질성 폐질환 1예

  • Lee, Kyoung Ju (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Kim, Jung Ha (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Ha, Eun Sil (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Jung, Jin Yong (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Lee, Seung Hyeun (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Kim, Se Joong (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Lee, Eun Joo (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Hur, Gyu Young (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Jung, Hye Cheol (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Lee, Sung Yong (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Kim, Hyn Koo (Department of Chest Surgery, College of Medicine, Korea University) ;
  • Lee, Sang Yeub (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Kim, Je Hyeong (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Shin, Chol (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Shim, Jae Jeong (Department of Internal Medicine, College of Medicine, Korea University) ;
  • In, Kwang Ho (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Kang, Kyung Ho (Department of Internal Medicine, College of Medicine, Korea University) ;
  • Yoo, Se Hwa (Department of Internal Medicine, College of Medicine, Korea University)
  • 이경주 (고려대학교 의과대학 내과학교실) ;
  • 김정하 (고려대학교 의과대학 내과학교실) ;
  • 하은실 (고려대학교 의과대학 내과학교실) ;
  • 정진용 (고려대학교 의과대학 내과학교실) ;
  • 이승현 (고려대학교 의과대학 내과학교실) ;
  • 김세중 (고려대학교 의과대학 내과학교실) ;
  • 이은주 (고려대학교 의과대학 내과학교실) ;
  • 허규영 (고려대학교 의과대학 내과학교실) ;
  • 정혜철 (고려대학교 의과대학 내과학교실) ;
  • 이승룡 (고려대학교 의과대학 내과학교실) ;
  • 김현구 (고려대학교 의과대학 흉부외과학교실) ;
  • 이상엽 (고려대학교 의과대학 내과학교실) ;
  • 김제형 (고려대학교 의과대학 내과학교실) ;
  • 신철 (고려대학교 의과대학 내과학교실) ;
  • 심재정 (고려대학교 의과대학 내과학교실) ;
  • 인광호 (고려대학교 의과대학 내과학교실) ;
  • 강경호 (고려대학교 의과대학 내과학교실) ;
  • 유세화 (고려대학교 의과대학 내과학교실)
  • Received : 2005.08.22
  • Accepted : 2005.09.15
  • Published : 2005.11.30

Abstract

Respiratory bronchiolitis associated interstitial lung disease is a rare condition among current or ex-smokers, which has features consistent with interstitial lung disease. The presentations are non-specific, but symptoms generally include a cough and dyspnea on exertion, and its pathology is characterized by the accumulation of pigmented macrophages within the respiratory bronchioles and adjacent air spaces, and is associated with mild thickening of the peribronchiolar interstitium. Recently, the case of a 54-year-old woman passive smoker, diagnosed as having respiratory bronchiolitis associated interstitial lung disease, was experienced at our institution.

저자들은 간접 흡연에 노출되어 운동 시 호흡곤란 및 지속적인 기침을 호소하는 54세 여자 환자에서 폐조직 생검상 호흡 세기관지염 연관 간질성 폐질환을 진단하였다. 간접 흡연력이 있는 자에서 RB-ILD를 진단한 증례는 국내에서 처음으로 이를 문헌 고찰과 함께 보고하는 바이다.

Keywords

References

  1. Niewoehner DE, Kleinerman J, Rice DB. Pathologic changes in the peripheral airways of young cigarette smokers. N Engl J Med 1974;291:755-8 https://doi.org/10.1056/NEJM197410102911503
  2. Myers JL, Veal CF Jr, Shin MS, Katzenstein AL. Respiratory bronchiolitis causing interstitial lung disease: a clinicopathologic study of six cases. Am Rev Respir Dis 1987;135:880-4 https://doi.org/10.1164/arrd.1987.135.4.880
  3. Yousem SA, Colby TV, Gaensler EA. Respiratory bronchiolitis-associated interstitial lung disease and its relationship to desquamative interstitial pneumonia. Mayo Clin Proc 1989;64:1373-80 https://doi.org/10.1016/S0025-6196(12)65379-8
  4. Moon J, du Bois RM, Colby TV, Hansell DM, Nicholson AG. Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease. Thorax 1999;54: 1009-14 https://doi.org/10.1136/thx.54.11.1009
  5. King TE Jr. Respiratory bronchiolitis-associated interstitial lung disease. Clin Chest Med 1993;14:693-8
  6. Park JS, Brown KK, Tuder RM, Hale VA, King TE Jr, Lynch DA. Respiratory bronchiolitis-associated interstitial lung disease: radiologic features with clinical and pathologic correlation. J Comput Assist Tomogr 2002;26:13-20 https://doi.org/10.1097/00004728-200201000-00003
  7. Kurumagawa T, Kobayashi H, Kanoh S, Nagata N, Aoki T, Aida S, et al. Respiratory bronchiolitis-associated interstitial lung disease. Nihon Kokyuki Gakkai Zasshi 1998;36:881-5
  8. Essadki O, Chartrand-Lefebvre C, Briere J, Grenier P. Respiratory bronchiolitis: radiographic and CT findings in a pathologically proven case. Eur Radiol 1998;8:1674-6 https://doi.org/10.1007/s003300050610
  9. Holt RM, Schmidt RA, Godwin JD, Raghu G. High resolution CT in respiratory bronchiolitis-associated interstitial lung disease. J Comput Assist Tomogr 1993;17:46-50 https://doi.org/10.1097/00004728-199301000-00007
  10. Wesselius LJ, Flowers CH, Skikne BS. Alveolar macrophage content of isoferritins and transferrin: comparison of nonsmokers and smokers with and without chronic airflow obstruction. Am Rev Respir Dis 1992; 145:311-6 https://doi.org/10.1164/ajrccm/145.2_Pt_1.311
  11. Liebow AA, Steer A, Billingsley JG. Desquamative Interstitial Pneumonia. Am J Med 1965;39:369-404 https://doi.org/10.1016/0002-9343(65)90206-8
  12. Hansell DM, Wells AU, Padley SP, Muller NL. Hypersensitivity pneumonitis: correlation of individual CT patterns with functional abnormalities. Radiology 1996;199:123-8 https://doi.org/10.1148/radiology.199.1.8633133
  13. Goeckenjan G. Respiratory bronchiolitis-associated interstitial lung disease (RB-ILD). Pneumologie 2003; 57:278-87 https://doi.org/10.1055/s-2003-39368
  14. McWilliams AM, Lake FR. Respiratory bronchiolitis associated interstitial lung disease (RB-ILD) presenting with haemoptysis. Respirology 2000;5:385-7 https://doi.org/10.1046/j.1440-1843.2000.00280.x
  15. Ahn BH, Park HS, Do JH, Suh GY, Chung MP, Rhee CH, et al. A case of respiratory bronchiolitis-asociated interstitial lung disease. Tuberc Respir Dis 1999;46: 103-9 https://doi.org/10.4046/trd.1999.46.1.103