Bronchoscopic Electrocautery with Electroprobe and Diathermic Snare in Patients with Malignant Airway Obstruction

중심성 폐암환자에서 악성 기도폐쇄에서 전기 탐침과 투열올가미를 사용한 전기 소작술의 효과

  • You, Hong Jun (Department of Internal Medicine, College of Medicine, Kosin University) ;
  • Choi, Pyoung Rak (Department of Internal Medicine, College of Medicine, Kosin University) ;
  • Park, Eun Ho (Department of Internal Medicine, College of Medicine, Kosin University) ;
  • Yang, Jae Hong (Department of Internal Medicine, College of Medicine, Kosin University) ;
  • Choi, In Su (Department of Internal Medicine, College of Medicine, Kosin University) ;
  • Kim, Hyoung Jun (Department of Internal Medicine, College of Medicine, Kosin University) ;
  • Kim, Joo Hoon (Department of Internal Medicine, College of Medicine, Kosin University) ;
  • Oak, Chul Ho (Department of Internal Medicine, College of Medicine, Kosin University) ;
  • Cho, Hyun Myung (Department of Internal Medicine, Wallace Memorial Baptist Hospital) ;
  • Jang, Tae Won (Department of Internal Medicine, College of Medicine, Kosin University) ;
  • Jung, Maan Hong (Department of Internal Medicine, College of Medicine, Kosin University)
  • 유홍준 (고신대학교 내과학교실 호흡기내과) ;
  • 최평락 (고신대학교 내과학교실 호흡기내과) ;
  • 박은호 (고신대학교 내과학교실 호흡기내과) ;
  • 양재홍 (고신대학교 내과학교실 호흡기내과) ;
  • ;
  • 김형준 (고신대학교 내과학교실 호흡기내과) ;
  • 김주훈 (고신대학교 내과학교실 호흡기내과) ;
  • 옥철호 (고신대학교 내과학교실 호흡기내과) ;
  • 조현명 (왈레스 기념 침례병원 호흡기내과) ;
  • 장태원 (고신대학교 내과학교실 호흡기내과) ;
  • 정만홍 (고신대학교 내과학교실 호흡기내과)
  • Received : 2005.07.20
  • Accepted : 2005.09.15
  • Published : 2005.11.30

Abstract

Background : Endobronchial tumors cause life-threatening dyspnea and can lower the quality of life due to central airway obstruction. In those cases with an intraluminal tumor, various bronchoscopic techniques are available for tumor debulking. The therapeutic effect of bronchoscopic electrocautery for palliation in patients with a symptomatic tumor obstruction was studied. Method : Nineteen patients with bronchogenic carcinomas (n=15) and metastatic tumors affecting the bronchi (n=4), between March 2002 and March 2005, were enrolled in this study. Electrocautery was performed under local anesthesia using an electroprobe and diathermic snare. Using flexible bronchoscopy, a follow-up bronchoscopic examination was performed 3-4 days later. Symptom improvement was evaluated by $FEV_1$, FVC and dyspnea score (Modified Borg Category Scale (0~10)), both before and after the electrocautery. Results : The success rate of electrocautery on the follow up examination was 84%. Patients with endoluminal airway lesions had a mean overall decrease in the size of the obstruction to $47.8{\pm}15.7%$. The mean Improvement in the dyspnea score immediately after the endobronchial tumor debulking was $2.78{\pm}1.42$. The average improvements in the $FEV_1$ and FVC after electrocautery were $0.32{\pm}0.19L$ and $0.5{\pm}0.22L$, respectively. There were 2 cases of complications related with electrocautery (one each of pneumothorax and pneumonia). Conclusion : Electrocautery using an electroprobe and diathermic snare was an effective and safe palliative treatment for a symptomatic endoluminal airway obstruction in lung cancer.

배 경 : 폐암의 경과 중 종양에 의한 기도폐쇄로 발생하는 호흡곤란은 환자의 삶의 질을 저하시키는 중요한 요인이다. 이런 환자들에서 전기탐침과 투열 올가미를 이용하여 굴곡성 기관지경을 통해 시행한 전기 소작술의 치료효과를 조사하였다. 방 법 : 기도를 침범한 종괴로 인해서 호흡곤란을 호소하는 19명의 폐암환자(편평상피암 14례, 선암 1례, 전이성 폐암 4례)를 대상으로 하였다. 평균 나이는 $61{\pm}10$세였으며 남자가 17명 여자가 2명이었다. 폐쇄부위는 기관이 2례, 주기관지가 17례였다. 국소마취 하에서 굴곡성 기관경을 통해 전기소작술을 총 29회 시행하였으며 소작시 30W의 전력을 사용하였다. 치료 전에 modified Borg category scale(0~10), 환기기능검사 및 기관지 내시경검사를 실시하였고 시술 후 3-4일 후에 modified Borg category scale(0~10)의 변화 및 환기기능 검사를 시행하였고, 정화 기관지경술(cleanup bronchoscopy)을 시행하여 기도폐쇄의 완화의 정도를 측정하였다. 결 과 : 시술 후 호흡곤란의 호전율은 84%였고 호흡곤란의 정도는 modified Borg category scale가 치료 전 $7.1{\pm}0.90$에서 $5.7{\pm}0.70$로, 기관지 내시경상 기도폐쇄 정도는 치료 전 $84{\pm}24.9%$에서 $69{\pm}22.1%$로 모두 유의하게 감소하였다. $FEV_1$과 FVC는 각각 $1.29{\pm}0.20L$, $2.04{\pm}0.34L$에서 치료 후 $1.72{\pm}0.75L$, $2.4.{\pm}0.3L$로 유의하게 호전되었다. 용종성 병변의 경우 전기 탐침을 이용하였을 때 보다 투열올가미를 사용한 때 평균 시술시간이 의미있게 감소하였다(각각 60분, 30분). 시술과 관련된 위험한 정도의 출혈, 부정맥, 그리고 사망은 없었다. 결 론 : 전기 탐침과 투열올가미를 이용한 굴곡성 기관지 경적 전기소작술은 종양에 의한 기도폐쇄로 발생하는 호흡곤란을 완화시키는데 효과적이고 안전하며 경제적인 치료방법이었다.

Keywords

References

  1. Smith EL, Hann DM, Ahles TA, Furstenberg CT, Mitchell CT, Meyer L et al. Dyspnea, anxiety, body consciousness, and quality of life in patients with lung cancer. J Pain Symptom Manage 2001;21:323-9 https://doi.org/10.1016/S0885-3924(01)00255-X
  2. Sutedja G, Postmus PE. Bronchoscopic treatment of lung tumors. Lung Cancer 1994;11:1-17
  3. Hooper RG, Jackson FN. Endobronchial electrocautery. Chest 1985;87:712-4 https://doi.org/10.1378/chest.87.6.712
  4. Wallace JM. Electrocautery via the fibroptic bronchoscope: a useful therapeutic technique? Chest 1985;87: 705-6 https://doi.org/10.1378/chest.87.6.705
  5. Gerasin VA, Shafirovsky BB. Endobronchial electrosurgery. Chest 1988;93:270-4 https://doi.org/10.1378/chest.93.2.270
  6. Themelin D, Duchatelet P, Boudaka W, Lamy V. End-oscopic resection of an endobronchial hypernephroma metastasis using polypectomy snare. Eur Respir J 1990;3:732-3
  7. Chung HS, Han SG, Shim YS, Kim KY, Han YC. Endobronchial electrosurgery: application of a newlydesigned probe in malignant airway obstruction. Tuberc Respir Dis 1990;37:74-82
  8. Sagawa M, Sato M, Takahashi H, Minowa M, Saito Y, Fujimura S. Electrosurgery with a fibroptic bronchoscope and a snare for endotracheal/endobronchial tumors. J Thorac Cardiovasc Surg 1998;116:177-9 https://doi.org/10.1016/S0022-5223(98)70263-6
  9. Muers MF, Round CE, Palliation of symptoms in nonsmall cell lung cancer: a study by the Yorkshire regional cancer organisation thoracic group. Thorax 1993;48: 339-43 https://doi.org/10.1136/thx.48.4.339
  10. Natalini G, Cavaliere S, Seramondi V, Foccoli P, Vitacca M, Ambrosino N, Candiani A. Curative bronchoscopic laser therapy for surgically resetable tracheobronchial tumors. Personal Experience J Bronchol 2002;9:90-5
  11. Methur PN, Wolf KM, Busk MF, Briete WM, Datzman M. Fiberoptic bronchoscopic cryotherapy in the management of tracheobronchial obstruction. Chest 1996;110: 718-23 https://doi.org/10.1378/chest.110.3.718
  12. Morice RC, Ece T, Ece F, Keus L. Endobronchial argon plasma coagulation for treatment of hemoptysis and neoplastic airway obstrucion. Chest 2001;119:781-7 https://doi.org/10.1378/chest.119.3.781
  13. Villanueva AC, Lo TC, Beamis JF Jr. Endobronchial brachytherapy. Clin Chest Med 1995;16:445-54
  14. Sutedja G, van Kralingen K, Schramel FM, Postmus P. Fibroptic bronchoscopy electrosurgery under local anesthesia for rapid palliation in patients with central airway malignancies: a preliminary report. Thorax 1994; 49:1243-6 https://doi.org/10.1136/thx.49.12.1243
  15. Boxem T, Muller M, Venmans B, Postmus P, Sutedja G. Nd-YAG laser vs bronchoscopic electrocautery for palliation of symptomatic airway obstruction. Chest 1999;116:1108-12 https://doi.org/10.1378/chest.116.4.1108
  16. Coulter TD, Mehta AC. The heat is on: impact of end-obronchial electrocautery on the need for Nd-YAG laser photoresection. Chest 2000;118:516-21 https://doi.org/10.1378/chest.118.2.516
  17. Cavaliere S, Venuta F, Foccoli P, Toninelli C, la Face B. Endoscopic treatment of malignant airway obstructions in 2008 patients. Chest 1996;110:1536-42 https://doi.org/10.1378/chest.110.6.1536
  18. Sutedja G, van Boxem T, Schramel F, et al. Endobronchial electrocautery is an excellent alternative for Nd:YAG laser to treat airway tumors. J Bronchol 1997;4:101-5 https://doi.org/10.1097/00128594-199704000-00002
  19. van Boxem TJ, Westerga J, Venmans BJ, Postmus PE, Sutedja TG. Tissue effects of bronchoscopic electrocautery. Chest 2000;117:887-91 https://doi.org/10.1378/chest.117.3.887