혜화의학회지 (Journal of Haehwa Medicine)
- 제14권2호
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- Pages.45-54
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- 2005
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- 2586-3002(pISSN)
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- 2586-3347(eISSN)
가미사물탕(GST)의 사이토카인으로 유도된 인간 섬유아세포양 활막 세포 활성화 저해 작용
Suppressive Effects of GST on Cytokine-induced Activation of Human Fibroblast-like Sinoviocytes
- Park, Jee-Young (Dept. of Pathology, College of Oriental Medicine, Daejeon University) ;
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Jin, Mi-Rim
(Dept. of Pathology, College of Oriental Medicine, Daejeon University) ;
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Kim, Dong-Hee
(Dept. of Pathology, College of Oriental Medicine, Daejeon University)
- 심사 : 2005.11.21
- 발행 : 2005.12.31
초록
GST, an extract from 16 herbs, has been formulated and prescribed for the treatment of human rheumatoid arthritis(hRA) for many years. The present study was done to investigate whether GST has suppressive effects on activation of fibroblast-like sinoviocytes isolated from an RA patient. In tumor necrosis factor-a(TNF-a)/interleukin-1b(IL-1b) treated human sinoviocytes, The mRNA expression of molecular indicators related to pathologic changes of the sinoviocytes were examined using quantitative real-time PCR. The treatment of GST(
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