Annals of Clinical Neurophysiology
- Volume 7 Issue 2
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- Pages.65-74
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- 2005
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- 2508-691X(pISSN)
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- 2508-6960(eISSN)
Diagnosis and treatment in Charcot-Marie-Tooth disease
샤르코-마리-투스 질환의 진단 및 치료
- Kim, Sang-Beom (Department of Neurology, College of Medicine, Ewha Womans University) ;
- Park, Kee Duk (Department of Neurology, College of Medicine, Ewha Womans University) ;
- Choi, Byung-Ok (Department of Neurology, College of Medicine, Ewha Womans University)
- Published : 2005.12.30
Abstract
Charcot-Marie-Tooth (CMT) disease was described by Charcot and Marie in France and, independently, by Tooth in England in 1886. CMT is the most common form of inherited motor and sensory neuropathy, and is a genetically heterogeneous disorder of the peripheral nervous system. Therefore, many genes have been identified as CMT-causative genes. Traditionally, subclassification of CMT have been divided into autosomal dominant inherited demyelinating (CMT1) and axonal (CMT2) neuropathies, X-linked neuropathy (CMTX), and autosomal recessive inherited neuropathy (CMT4). Recently, intermediate type (CMT-Int) with NCVs between CMT1 and CMT2 is considered as a CMT type. There are several related peripheral neuropathies, such as