Korean Journal of Clinical Laboratory Science (대한임상검사과학회지)
- Volume 37 Issue 3
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- Pages.197-206
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- 2005
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- 1738-3544(pISSN)
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- 2288-1662(eISSN)
Mast Cells and Vascular Endothelial Growth Factor Expression in Neoangiogenesis of Cervical Intraepithelial Neoplasia and Invasive Squamous Cell Carcinomas of the Uterine Cervix
자궁경부상피내종양과 침윤성 편평상피암종의 혈관신생에서 비만세포와 혈관내피성장인자의 발현
- Jekal, Seung-Joo (Department of Clinical Laboratory Science, Wonkwang Health Science College) ;
- Lee, Jung-Ah (Deparment of Pathology, Wonkwang University Hospital) ;
- Rho, Jong-Sup (Deparment of Pathology, Wonkwang University Hospital)
- Published : 2005.12.30
Abstract
To determine the correlation between mast cells(MCs) and neoangiogenesis in the growth and progression of cervical cancer, we investigated mast cell density(MCD), microvessel density(MVD) and the expression of vascular epithelial growth factor(VEGF) in cervical intraepithelial neoplasia and invasive suqamous cell carcinoma of the uterine cervix. Forty-five cervical intraepithelial neoplasia(CIN I, II and III), 15 microinvasive carcinomas, 15 invasive squamous cell carcinomas and 20 normal cervical epithelia were included in this study. MCs were stained with anti-c-Kit antibody and alcian blue, microvessels with anti-factor VIII antibody and VEGF with anti-VEGF antibody. The adjacent fields of both normal and neoplastic epithelium were used for counting MCs and microvessels. Computerized image analysis was used to evaluate MCD and MVD. MCD and MVD were the mean numbers per