Journal of the Korean Data and Information Science Society

The Korean Data and Information Science Society (한국데이터정보과학회)
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Analysis on the Amino Acid Distributions with Position in Transmembrane Proteins

  • Chi, Sang-Mun (Department of Computer Science, College of Multimedia, Kyungsung University)
  • Published : 2005.11.30
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Abstract

This paper presents a statistical analysis on the position-specific distributions of amino acid residues in transmembrane proteins. A hidden Markov model segments membrane proteins to produce segmented regions of homogeneous statistical property from variable-length amino acids sequences. These segmented residues are analyzed by using chi-square statistic and relative-entropy in order to find position-specific amino acids. This analysis showed that isoleucine and valine concentrated on the center of membrane-spanning regions, tryptophan, tyrosine and positive residues were found frequently near both ends of membrane.

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