Journal of Periodontal and Implant Science

  • 제35권4호
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  • Pages.1053-1071
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  • 2005
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  • 2093-2278(pISSN)
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  • 2093-2286(eISSN)
대한치주과학회 (Korean Academy of Periodontology)
권호 표지

천연추출물 Curcuma xanthorriza oil 함유치약의 치태 및 치은염 억제효과

Suppressive effect of Curcuma xanthorrhiza oil on plaque and gingivitis

  • 홍지연 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소) ;
  • 김상년 (LG 생활건강 R&D Park) ;
  • 하원호 (LG 생활건강 R&D Park) ;
  • 장석윤 (LG 생활건강 R&D Park) ;
  • 장인권 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소) ;
  • 박지은 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소) ;
  • 정성원 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소) ;
  • 엄유정 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소) ;
  • 최성호 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소, BK21 의과학 사업단) ;
  • 김종관 (연세대학교 치과대학 치주과학교실, 치주조직 재생연구소, BK21 의과학 사업단)
  • Hong, Ji-Youn (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Kim, Sang-Nyun (LG Household & Healthcare R&D Park) ;
  • Ha, Won- Ho (LG Household & Healthcare R&D Park) ;
  • Chang, Sug-Youn (LG Household & Healthcare R&D Park) ;
  • Jang, In-Kwon (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Park, Ji-Eun (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Jung, Sung-Won (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Um, Yoo-Jung (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration) ;
  • Choe, Seong-Ho (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 Project for Medical Science.) ;
  • Kim, Chong-Kwan (Department of Periodontology, College of Dentistry, Yonsei University, Research Institute for Periodontal Regeneration, Brain Korea 21 Project for Medical Science.)
  • 발행 : 2005.12.31
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초록

To find out the suppressive effect of natural extract Curcuma xanthorrhiza on $IL-1{\beta}$ and MMP-2 derived from periodontal ligament cells through in vitro study and to confirm its effect on plaque and gingivitis through clinical study, Curcuma xanthorrhiza containing toothpaste was used and following results were produced. 1. In vitro study, type IV collagenase MMP-2 production was inhibited dose-dependently in the group treated with Curcuma xanthorrhiza compared to the control group. 2. In vitro study, the production of $IL-l{\beta}$ which is one of the inflammatory mediators associated with periodontitis was inhibited dose-dependently in the group treated with Curcuma xanthorrhiza. 3. On the third week, the plaque index of the groups treated with or without Curcuma xanthorrhiza containing toothpastes were both increased significantly compared to the baseline(p<0.05). 4. On the third week, the gingival index of the group treated with Curcuma xanthorrhiza containing toothpaste was not significantly different from baseline. However, the group treated without Curcuma xanthorrhiza containing toothpaste showed a significant increase of gingival index at shielded area(p<0.05). 5. The gingival index of the group without Curcuma xanthorrhiza containing toothpaste showed a significant increase in the sites without tooth brushing when compared to sites with tooth brushing(p<0.05). However. there was no significant difference for the group with Curcuma xanthorrhiza containing toothpaste in sites either with or without tooth brushing. 6. The Bleeding on probing for the group without Curcuma xanthorrhiza containing toothpaste showed no significant difference even when tooth brushing was done. However, for the group with Curcuma xanthorrhiza containing toothpaste, bleeding on probing was significantly reduced compared to baseline when tooth brushing was done(p<0.05).

키워드

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