Journal of Life Science (생명과학회지)

Korean Society of Life Science (한국생명과학회)
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The Effects of Hijikia fusiforme on Serum Lipid Levels in Ovariectomized Rats

톳이 난소를 절제한 흰쥐의 지질 농도 변화에 미치는 영향

  • Kim Jeang-Yub (Dept. of Food Science and Nutrition, Silla University) ;
  • Kim Mihyang (Dept. of Food Science and Nutrition, Silla University)
  • 김정엽 (신라대학교 식품영양학과) ;
  • 김미향 (신라대학교 식품영양학과)
  • Published : 2005.04.01
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Abstract

The aim of this study was evaluated the effect of biological activity of Hijikia fusiforme (HF). To investigate the effects of biological activity of HF ethanol extracts, Sprague-Dawley female rats were randomly assigned to the following groups: sham-operated rats (Sham), ovariectomized control rats (OVX-control), ovariectomized rats supplemented ethanol extracts of HF at 50 mg/kg bw/day (OVX-HF50), ovariectomized rats supplemented ethanol extracts of HF at 200 mg/kg bw/day (OVX-HF200). HF ethanol extracts were orally supplemented at the level of 1 mL per day. The body weight gain, food intake and food efficiency ratio were not significantly different between groups. Although total-cholesterol and triglyceride were increased in the ovariectomized control, supplementation with the HF extracts decreased the levels. And HDL-cholesterol levels were significantly increased after supplementation with the HF extracts $(p<0.05)$. According to these results, we could known the effects biological activity of Hijikia fusiforme. Consequently, we expect the effects of Hijikia fusiforme extract on cardiovascular diseases aging coming from postmenopausal.

폐경을 앞둔 여성에서는 폐경기 증후군, 허혈성 심장질환의 발생빈도증가 등의 문제점을 가지고 있다. 그러므로 해조류 중 톳 추출물을 인위적으로 갱년기 장애를 유도한 흰쥐에 투여하여 혈 중 지질 농도변화에 미치는 영향을 검토하였다. 난소 절제에 의한 estrogen부족이 심혈관계 질환에 영향을 미치는 결과를 초래하는 지질대사에서는 total-cholesterol과 중성지방의 경우 난소절제에 의해 증가된 함량이 톳 추출물을 투여함으로써 감소하는 경향을 보였다. 또한 혈 중 HDL-cholesterol은 톳 추출물 모두 난소절제한 군과 비교해서 유의적 높은 경향을 나타내어 혈중 지질조성 개선에 톳이 유효한 효과를 나타내었다. 본 실험의 결과로부터 갱년기 장애시 유발되는 지질대사 이상으로 오는 심혈관계 질환에 톳 추출물이 유효한 효과를 줄 것으로 사료되며 또한 잘못된 식습관으로 오는 비만에도 유익한 효과를 가져다 줄 것으로 기대된다.

Keywords

References

  1. Min, B. G. and B. S. Gu. 1985. The study of posternenopausal women in Korea (1). Korean soc. Obstet. Gynecol. 28, 966-969
  2. van Keep, P.A., J. M. Kellerhals. 1973. The aging woman. Front. Horm. Res. 2, 6-12
  3. Ross, R. K., A. Pagamm-Hill, T. M. Mark and B. E. Henderson. 1989. Cardiovascular benefits of estrogen replacement therapy. Am. J. Obstet Gynecol. 160, 1301-1306 https://doi.org/10.1016/S0002-9378(89)80017-1
  4. Campos, H., W. F. Wilson Peter, D. Jimenez, J. R. Mcnamara, J. Ordovas and E. J. Schaefer. 1990. Differences in apolipoproteins and low density lipoprotein subfractions in postmenopausal women on and off estrogen therapy, Results from the Framingham offspring study. Metabolism 39, 1033-1038 https://doi.org/10.1016/0026-0495(90)90162-6
  5. Kwon S.C. 1998. Effects of Continuously Added Oral Progestin (Medroxy-progesterone Acetate) on the Levels of Serum Lipid and Lipoprotein during Estrogen Replacement Therapy in Postemenopausal Women. Korean soc. Obstet. Gynecol. 41, 2442-2446
  6. Stroheker, T., N. Cabaton, R. Berges and V. Lamothe. 2003. Influence of dietary soy isoflavones on the accessory sex organs of the Wistar rat. Food and Chemical Toxicology 41, 1175-1183 https://doi.org/10.1016/S0278-6915(03)00108-X
  7. Abdussalam, S. 1990. Drugs from seaweeds. Med. Hypotheses 32, 33-35 https://doi.org/10.1016/0306-9877(90)90064-L
  8. Hwang, E.K., C.S. Park and C. H. Sohn. 1997. Conditions on theearly growth of Hizikiafusiformis (phaeeophyta). Bull. Korean Fisheries Soc. 10, 199-211
  9. Koo, J. G., J. S. Jo, J. R. Do, J. H. Park and C. B. Yang. 1995. Chemical propeties of fucoidans from Hizikia fusiformis and Sargassum fuluellum. Bull. korean Fisheries Soc. 28, 659-666
  10. Do, J. R, E. M. Kim, J. G. Koo and K. S. Jo. 1997. Dietary fiber contents of marine algae andextraction condition of the fiber. Bull. Korean. Fisheries Soc. 30, 291-296
  11. Kim, S.H., S.B. Lim, Y. H. Ko, M. C. Oh and C. S. Park. 1994. Extracton yields of Hizikiafusiforme by solvents and their antimicrobial effects. Bull. Korean Fisheris Soc. 27, 462-468
  12. Kim, H.S. and G. J. Kim. 1998. Effects of the feeding Hijikia fu-siforme (Harvey) okamura on lipid composition of serum in dietary hyperlipidemic rats. J. Korean Soc. Food Sci. Nutr. 27, 718-723
  13. Wronski, T. J., M. Cintron and L. M. Dann. 1988. Temporal relationship between bone loss and increased bone turnover in ovariectomized rats. Calcif Tissue Int. 43, 179-183 https://doi.org/10.1007/BF02571317
  14. Abe, T., J. W. M. Chow, J. M. Lean and T. J. Chambers. 1993. Estrogen does not restore bone list after ovariectomy in the rat. J. Bone Miner. Res. 8, 831-838
  15. Aitken, J. M, E. Armstrong and J. B. Anderson. 1972. Osteroporosis after ophoretomy in the mature female rat and the effect of estrogen and/ or progesterone replacement therapy in its prevention. J. Endocrinol. 55, 79-87 https://doi.org/10.1677/joe.0.0550079
  16. Ramirez, M. E., M. P. McMurry, G. A Wiebke, K. J. Felton and K. Ren. 1997. Evidence for sex steroid inhibition of lipoprotein lipase in men; comparison of abdominal and femoral adipose tissue. Metabolism 46. 179-185 https://doi.org/10.1016/S0026-0495(97)90299-7
  17. Valette, A., K. M. Meignen, L. Mercier, J. G. Liehr and J. Boyer. 1986. Effects of 2-fluoroestradiol on lipid metabolism in the ovariectomized rat. J. Steroid Biochem. 25, 575-578 https://doi.org/10.1016/0022-4731(86)90405-X
  18. The Association of Korean Clinical Pathology. 1994. The clinical pathology. Korea Medicine Co, Seoul 40-79
  19. Ortho Clinical Diagnostics. 2001. The reference intervals in biochemical analyse of laboratory animal. Johnson-Johnson Co, New York 13-17
  20. Park Young-Hee, Sun Yoon, Tae-Moo Yoo, 2001. The Effect of lsoflavone Supplementation on Bone Metabolism in Ovariectomized SD rats. J. Korean Soc. Food Sci. Nutr. 30, 657-661
  21. Beeson, P. B., W. McDermott and J. B. Wyngaarden. 1979. Text book of medicine. Saunders Co. philadelphia 77-100
  22. Guyton. 1994. Text book of medical physiology. 8th ed., Saunders Co., philadelphia 754-764
  23. Corine, H. Rand S. W. Emma. 1984. Basic nutrition and diet therapy. 5th ed., Macmillan Co., New York 272-273
  24. Baker, H. J., J. R Lindsey and S. H. Weisbroth. 1984. The laboratory rats. Academic Press Inc., New York II, 123-127
  25. The Association of Korean Clinical Pathology. 1994. The clinical pathology. Korean Medicine Co. 40-79
  26. Korean Biochemical Association. 1985. Experimental biochemistry. Tamgudangm. Seoul 130-150
  27. Lipid Research Clinics Program. 1984. The Research Clinic Primary Prevention Trial results. II. The relationship of reduction of indence of coronary heart disease to cholesterol lowering. JAMA. 251, 365-374 https://doi.org/10.1001/jama.251.3.365
  28. Cho, S. Y. and J. Y. Park. 2000. Effect of dandelion leaf extracts on lipid metabolism in rats fed high cholesterol diet. J. Korean Sci. Nutr. 29, 676-682
  29. National Institutes of Health consensus development conference. 1985. Statement Lowering blood cholesterol to prevent heart disease. JAMA 253, 2080-2086 https://doi.org/10.1001/jama.253.14.2080
  30. Cho, Sung-Hee and S. W. Choi. 2001. Effects of Defatted Safflower and Perilla Seed Powders on Lipid Metabolism in Ovariectomized Female Rats Fed High Cholesterol Diets. J. Korean Soc. Food Sci. Nutr 30, 112-118
  31. Lee, Y. J. and Y. K. Kim. 2003. High science of Nutrition. 76-78. Sinkong Press Inc
  32. Choi, Jin-Ho and Kim, Dong-Woo. 1999. Effects of Brown Algae (Undaria pinnatifida)-Noodle on lipid metabolism in serum of SD-Rats. J. Korean Fish. Soc. 32, 42-49
  33. Eastwood M. 1987. Dietary fiber and the risk of cancer. Nutr. Rev. 45, 193-199 https://doi.org/10.1111/j.1753-4887.1987.tb02730.x
  34. Yang. J. L. 1996. Effects of dietary fibers on cholesteol metabolism in cholesterol fed rats. J. Korean Soc. Food Sci. Nutr. 25, 392-398

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