대한세포병리학회지 (The Korean Journal of Cytopathology)

대한세포병리학회 (The Korean Society for Cytopathology)
권호 표지

뇌척수액 세포검사를 통해 발견된 원발성 아교모세포종증 -증례 보고-

Primary Leptomeningeal Glioblastomatosis Detected in Cerebrospinal Fluid Cytology -A Case Report-

  • 장기석 (한양대학교 의과대학 병리학교실) ;
  • 장시형 (한양대학교 의과대학 병리학교실) ;
  • 송영수 (한양대학교 의과대학 병리학교실) ;
  • 박문향 (한양대학교 의과대학 병리학교실)
  • Jang, Ki-Seok (Department of Pathology, College of Medicine, Hanyang University) ;
  • Jang, Si-Hyong (Department of Pathology, College of Medicine, Hanyang University) ;
  • Song, Young-Soo (Department of Pathology, College of Medicine, Hanyang University) ;
  • Park, Moon-Hyang (Department of Pathology, College of Medicine, Hanyang University)
  • 발행 : 2005.11.30
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초록

Primary leptomeningeal glioblastomatosis is a rare and fatal tumor of the central nervous system, the condition is characterized by diffuse infiltration of the tumor in the meninges without evidence of primary tumor within the brain or spinal cord. We reported an unusual case of leptomengial glioblastomatosis, which was detected by the consecutive cerebrospinal fluid (CSF) cytology with application of immunohistochemistry, in addition to its cytologic findings. A healthy 21 year old man, who was enlisted in the army, presented with a stuporous mental state and diffuse enhancement of meninges without evidence of primary mass lesion in the brain and spinal cord on magnetic resonance imaging(MRI). CSF cytology showed small loose clusters of tumor cells with single cells and lymphocytes. The tumor showed variable pleomorphism with coarse chromatin, irregular nuclear membranes and multi lobated nuclei. On immunohistochemical staining, the tumor cells were founded to be positive for GFAP. In conjunction with radiologic findings, brain biopsy confirmed the diagnosis of leptomenigeal glioblastomatosis. The use of immunohistochemistry is helpful in confirming CSF cytologic diagnosis in patients with primary leptomeningeal glioblastomatosis.

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참고문헌

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