대한세포병리학회지 (The Korean Journal of Cytopathology)

대한세포병리학회 (The Korean Society for Cytopathology)
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HIV 음성 환자에서 형질모세포종의 세침흡인 세포소견 - 1예 보고 -

Fine Needle Aspiration Cytology of the Plasmablastic Lymphoma in Human Immunodeficiency Virus (HIV) Negative Patient - A Case Report -

  • 이향임 (울산대학교 의과대학 서울아산병원 진단병리과) ;
  • 구현령 (울산대학교 의과대학 서울아산병원 진단병리과) ;
  • 한은미 (고려대학교 안산병원 병리과) ;
  • 공경엽 (울산대학교 의과대학 서울아산병원 진단병리과) ;
  • 서철원 (울산대학교 의과대학 서울아산병원 내과) ;
  • 류민희 (울산대학교 의과대학 서울아산병원 내과) ;
  • 강윤구 (울산대학교 의과대학 서울아산병원 내과) ;
  • 박찬정 (울산대학교 의과대학 서울아산병원 진단검사의학과) ;
  • 허주령 (울산대학교 의과대학 서울아산병원 진단병리과)
  • Lee, Hyang-Im (Department of Pathology, Asan Medical Center, Ulsan University) ;
  • Koo, Hyun-Ryung (Department of Pathology, Asan Medical Center, Ulsan University) ;
  • Han, Eun-Mee (Department of Pathology, Ansan Hospital, Korea University) ;
  • Gong, Gyung-Yub (Department of Pathology, Asan Medical Center, Ulsan University) ;
  • Suh, Chul-Won (Department of Internal Medicine, Asan Medical Center, Ulsan University) ;
  • Ryu, Min-Hee (Department of Internal Medicine, Asan Medical Center, Ulsan University) ;
  • Kang, Yoon-Goo (Department of Internal Medicine, Asan Medical Center, Ulsan University) ;
  • Park, Chan-Jeong (Department of Clinical Pathology, Asan Medical Center, Ulsan University) ;
  • Huh, Joo-Ryung (Department of Pathology, Asan Medical Center, Ulsan University)
  • 발행 : 2005.05.31
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초록

Plasmablastic lymphoma (PBL) is a recently described aggressive B-cell neoplasm, which usually manifests as a localized disease of the oral mucosa in individuals infected with human immunodeficiency virus (HIV). Recently we encountered a case of plasmablastic lymphoma manifesting in the left maxillary sinus and cervical lymph node of a previously healthy HIV-negative man, 48 years of age. we conducted a fine-needle aspiration smear of the cervical lymph node, and this was found to be highly cellular with numerous large cells exhibiting eccentrically positioned nuclei, prominent nucleoli, and moderate quantities of basophilic cytoplasm. A biopsy of the mass in the maxillary sinus evidenced diffuse growth of similar plasmablastic cells. These tumor cells were negative for the leukocyte common antigens, CD20, CD3, CD30, and EMA. However, the cells tested positive for CD79a and CD138/syndecan-1. The tumor cells also exhibited L-light-chain restriction. The Ki-67 proliferation index was measured at almost 100%. The patient was diagnosed with plasmablastic lymphoma. After three cycles of combination chemotherapy and radiotherapy, the patient went into complete remission, and currently remains in this state.

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참고문헌

  1. Delecluse HJ, Anagnostopoulos I, Dallenbach F, Hummel M, Marafioti T, Schneider U, et al. Plasmablastic lymphomas of the oral cavity: A new entity associated with the human immunodeficiency virus infection. Blood 1997;89:1413-20
  2. Carbone A, Gloghini A, Canzoniery V, Tirelli U, Gaidano G. AIDS-related extranodal non-Hodgkinis lymphoma with plasma cell differentiation. Blood 1997;90:1337-8
  3. Chetty R, Hlatswayo N, Muc R, Sabaratnam R, Gatter K. Plasmablastic lymphoma in HIV+ patients: an expanding spectrum. Histopathology 2003;42:605-9 https://doi.org/10.1046/j.1365-2559.2003.01636.x
  4. Lin Y, Rodrigues GD, Turner JF, Vasef MA. Plasmablastic lymphoma of the lung: Report of a unique case and review of the literature. Arch Pathol Lab Med 2001;125:282-5
  5. Pruneri G, Graziadei G, Ermellino L, Baldini L, Neri A, Buffa R. Plasmablastic lymphoma of the stomach: A case report. Haematologica 1998;83:87-9
  6. Lin F, Zhang K, Quiery A, Prichard J, Schuerch C. Plasmablastic lymphoma of the cervical lymph nodes in a human immunodeficiency virus-negative patient: a case report and review of the literature. Arch Pathol Lab Med 2004;128:581-4
  7. Nguyen DD, Loo BW, Tillman G, Natkunam Y, Cao TM, Vaughan W, et al. Plasmablastic lymphoma presenting in a human immunodeficiency virus- negative patient: a case report. Ann Hematol 2003;82:521-5 https://doi.org/10.1007/s00277-003-0684-3
  8. Colomo L, Loong F, Rives S, Pittalugas, Martinez A, Lopez-Guillermo A, et al. Diffuse Large B-cell lymphomas with plasmablastic differentiation represent a heterogeneous group of disease entities. Am J Surg Pathol 2004;28:736-47 https://doi.org/10.1097/01.pas.0000126781.87158.e3
  9. Stewart JM, Krishnamurthy S. Fine-needle aspiration cytology of a case of HIV-associated anaplastic myeloma. Diagn Cytol 2002;27:218-22 https://doi.org/10.1002/dc.10174
  10. Geodert JJ. The epidemiology of acquired immunodeficiency syndrome malignancies. Semin Oncol 2000;27:390-401