대한한방부인과학회지 (The Journal of Korean Obstetrics and Gynecology)
- 제18권3호
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- Pages.32-50
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- 2005
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- 1229-4292(pISSN)
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- 2508-3619(eISSN)
생혈보수탕(生血補髓湯)이 난소적출 흰쥐 대퇴골의 형태계측학적 변화 및 골대사 관련인자에 미치는 영향
Effects of Saenghyeolbosu-Tang on the Morphometric Changes of Femur, and on the Factors Related with Bone Metabolism in Ovariectomized Rats
- Jeong, Jae-Sook (Dept. of Oriental Gynecology, College of Oriental Medicine, Se-Myung University) ;
- Seo, Il-Bock (Dept. of Oriental Gynecology, College of Oriental Medicine, Se-Myung University) ;
- Kim, Hyung-Jun (Dept. of Oriental Gynecology, College of Oriental Medicine, Se-Myung University)
- 발행 : 2005.08.31
초록
Purpose : This study was carried out to investigated the effects of Saenghyeolbosu-Tang on the morphometric changes of femur, and on the hormones and cytokines associated with bone metabolism in ovariectomized rats. Methods : Twenty-four female Sprague-Dawley rats were divided into sham operated group(normal), ovariectomized group(control), and treated with extract of Saenghyeolbosu-Tang group(treated). Each group was evaluated the changes of body weight at 0, 3, 6, 8, weeks after ovariectomy. Morphometric analysis(femur weight, femur/body weight, femur ash weight, femur ash/body weight, cross sectional area of compact bone and cancellous bone of femur) and histopathological examination were performed at 8 weeks after ovariectomy. Estrogen and cytokines(