Prognostic Factors of Pyogenic Spinal Infections

  • Jung, Young-Jin (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Kim, Sang-Woo (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Chang, Chul-Hoon (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Kim, Seong-Ho (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Kim, Oh-Lyong (Department of Neurosurgery, College of Medicine, Yeungnam University) ;
  • Cho, Soo-Ho (Department of Neurosurgery, College of Medicine, Yeungnam University)
  • 발행 : 2005.12.28

초록

Objective : This study is performed to evaluate the clinical manifestations and prognostic factors among patients with pyogenic spinal infections. Methods : The records and radiologic data of 27 patients treated between 2001 and 2003 were retrospectively evaluated. Results : All patients [mean age, 55.2yrs] were treated with i.v. antibiotics and 13[48.1%] required surgical treatment. Mean follow up duration was 38.9 weeks. The sixteen patients[59.2%] had previous surgical procedure on spine and six patients[22.0%] had local injections. The ten patients had predisposing factor [such as, diabetes mellitus, UTI, liver cirrhosis, septic condition]. The most common symptoms are lower back pain and motor weakness. Causative organisms determined only in ten patients[37%] and Staphylococcus aureus[50%] was most common. C-reactive protein[CRP] and white blood cell[WBC] count were more correlated with clinical outcome than erythrocyte sedimentation rate[ESR]. Conclusion : CRP and WBC level can be significant parameters of treatment and prognosis in pyogenic spinal infection.

키워드

참고문헌

  1. Abdel-Magid RA, Kotb HI : Epidural abscess after spinal anesthesia : a favorable outcome. Neurosurgery 27 : 310-311, 1990 https://doi.org/10.1227/00006123-199008000-00025
  2. Altrochi PH : Acute transverse myelopathy. Arch Neurol 168 : 111-119, 1963
  3. Barker AS, Ojemann RG, Swartz MN, Richardson EP Jr. : Spinal epidural abscess. N Engl J Med 293 : 463-468, 1975 https://doi.org/10.1056/NEJM197509042931001
  4. Bergman I, Wald ER, Meyer JD, Painter MJ : Epidural abscess and vertebral osteomyelitis following serial lumbar puntures. Pediatrics 72 : 476-480, 1983
  5. Chew FS, Kline MJ : Diagnositc yield of CT-guided percutaneous aspiration procedures in suspected spontaneous infectious diskitis. Radiology 218 : 211-214, 2001 https://doi.org/10.1148/radiology.218.1.r01ja06211
  6. Crenshaw AH : Campbell's Operative Orthopedics. 8th ed., Saint Louis : The CB Mosby company, 1992, pp3802-3823
  7. Danner RL, Hartman BJ : Update on spinal epidural abscess; 35 cases and review of the literature. Rev Infect Dis 9 : 265-274, 1987 https://doi.org/10.1093/clinids/9.2.265
  8. Del Curling O Jr, Gower DJ, McWhorter JM : Changing concepts in spinal epidural abscess : A report of 29 cases. Neurosurgery 27 : 185-192, 1990 https://doi.org/10.1227/00006123-199008000-00002
  9. Gerszten PC, Gerszten E, Allison MJ : Diseases of the spine in South American mummies. Neurosurgery 48 : 208-213, 2001 https://doi.org/10.1097/00006123-200101000-00039
  10. Heusner AP : Nontuberculous spinal epidural infection. N Engl J Med 239 : 845-854, 1948 https://doi.org/10.1056/NEJM194812022392301
  11. Hlavin ML, Kaminski JH, Ross JS, Ganz E : Spinal epidural abscess : A-ten-year perspective. Neurosurgery 27 : 177-184, 1990 https://doi.org/10.1227/00006123-199008000-00001
  12. Hwang GJ, Kuh SU, Chin DK, Cho YE, Kim YS : Management of wound infection after lumbar spine fusion with instruments. J Korean Neurosurg Soc 35 : 36-41, 2004
  13. H. Richard W : Younmans Neurological Surgery, 5th ed. Philadelphia : Saunders, 2004, pp4363-4394
  14. Khanna RK, Malik GM, Rock JP, Rosenblum ML : Spinal epidural abscess : evaluation of factors influencing outcome. Neurosurgery 39 : 958-964, 1996 https://doi.org/10.1097/00006123-199611000-00016
  15. Kim H, Oh SH, Choi IS, Bak KH, Kim YS, Kim CH, et al : Acute panspinal epidural abscess. J Korean Neurosurg Soc 28 : 392-397, 1999
  16. Kim HC, Kim CH, Cheong JH, Kak KH, Kim JM, Oh SJ, et al : Instrument-related complications following lumbar trandpedicular screw fixation. J Korean Neurosurg Soc 31: 533-539, 2002
  17. Kim JH, Lim SJ, Cho TH, Park JY, Lee HK, Suk JK, et al : Clinical analysis of re-operation after thoracic and lumbar spinal fusion surgery. J Korean Neurosurg Soc 31 : 107-112, 2002
  18. Koppel BS, Tuchman AJ, Mangiardi JR, Daras M, Weitzner I : Epidural spinal infection in intravenous drug abusers. Arch Neurol 45 : 1331- 1337, 1988 https://doi.org/10.1001/archneur.1988.00520360049011
  19. Loarie DJ, Fairley HB : Epidural abscess following spinal anesthesia. Anesth Analg 57 : 351-353, 1978
  20. Macnab I : Nagtive disc esploration. An analysis of the cause of nerveroot involvement in sixty-eight patients. J Bone Joint Surg 53A : 891- 903, 1971
  21. Martin S, Thomas W : Spinal epidural abscesses : Clinical manifestations, prognostic factors, and outcomes. Neurosurgery 51 : 79-82, 2002 https://doi.org/10.1097/00006123-200207000-00013
  22. Messer HD, Litvinoff J : Pyogenic cervical osteomyelitis. Chondroosteomyelitis of the cervical spine frequently associated with parenteral drug use. Arch Neurol 33 : 571-576, 1976 https://doi.org/10.1001/archneur.1976.00500080049007
  23. Park SB, Lee KC, Park YS, Lee BY, Kang S : A case of spontaneous spinal epidural abscess. J Korean Neurosurg Soc 22 : 551-557, 1993
  24. Rigamonti D, Liem L, Sampath P, Knoller N, Namaguchi Y, Schreibman DL, et al : Spinal epidural abscess : Contemporary trends in etiology, evaluation, and management. Surg Neurol 52 : 189-196, 1999 https://doi.org/10.1016/S0090-3019(99)00055-5
  25. Sarrel WG, Lafia DJ : Acute lumbar epidural abscess : report of a case. Engl J Med 250 : 318-320, 1954 https://doi.org/10.1056/NEJM195402252500804
  26. Strong WE : Epidural abscess associated with epidural catheterization : A rare event? Report of two cases with markedly delayed presentation. Anesthesiology 74 : 943-946, 1991 https://doi.org/10.1097/00000542-199105000-00024
  27. Tang HJ, Lin HJ, Liu YC, Li CM : Spinal epidural abscess-experience with 46 patients and evaluation of prognostic factors. J Infect 45 : 76- 81, 2002 https://doi.org/10.1053/jinf.2002.1013
  28. Verner EF, Musher DM : Spinal epidural abscess. Med Clin North Am 69 : 375-384, 1985 https://doi.org/10.1016/S0025-7125(16)31049-5
  29. Yang TK, Kim KS, Lee JC : Chronic spinal epidural abscess after epidural analgesia. J Korean Neurosurg Soc 33 : 599-601, 2003