References
- Mandal, P.K. Dioxin: a review of its environmental effects and its aryl hydrocarbon receptor biology. J. Comp. Physiol. [B] 175, 221-230. Epub 2005 Apr 8. (2005). https://doi.org/10.1007/s00360-005-0483-3
- Fisher, M.T., Nagarkatti, M. & Nagarkatti, P.S. Combined screening of thymocytes using apoptosis-specific cDNA array and promoter analysis yields novel gene targets mediating TCDD-induced toxicity. Toxicol. Sci. 78, 116-124. Epub 2004 Jan 12. (2004) https://doi.org/10.1093/toxsci/kfh056
- Korkalainen, M., Tuomisto, J. & Pohjanvirta, R. Primary structure and inducibility by 2, 3, 7, 8-tetrachlorodibenzo- p-dioxin (TCDD) of aryl hydrocarbon receptor repressor in a TCDD-sensitive and a TCDDresistant rat strain. Biochem. Biophys. Res. Commun. 315, 123-131 (2004) https://doi.org/10.1016/j.bbrc.2004.01.028
- Ishizuka, M., Yonemoto, J., Zaha, H., Tohyama, C. & Sone, H. Perinatal exposure to low doses of 2, 3, 7, 8- tetrachlorodibenzo-p-dioxin alters sex-dependent expression of hepatic CYP2C11. J. Biochem. Mol. Toxicol. 17, 278-285 (2003)
- Davis, B.J., McCurdy, E.A., Miller, B.D., Lucier, G.W. & Tritscher, A.M. Ovarian tumors in rats induced by chronic 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin treatment. Cancer Res. 60, 5414-5419 (2000)
- Schwarz, M., Buchmann, A., Stinchcombe, S., Kalkuhl, A.&Bock, K. Ah receptor ligands and tumor promotion: survival of neoplastic cells. Toxicol. Lett. 112- 113, 69-77 (2000)
- Walker, N.J., Tritscher, A.M., Sills, R.C., Lucier, G.W. & Portier, C.J. Hepatocarcinogenesis in female Sprague-Dawley rats following discontinuous treatment with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Toxicol. Sci. 54, 330-337 (2000) https://doi.org/10.1093/toxsci/54.2.330
- Milstone, L.M. & LaVigne, J.F. 2, 3, 7, 8-Tetrachlorodibenzo- p-dioxin induces hyperplasia in confluent cultures of human keratinocytes. J. Invest. Dermatol. 82, 532-534 (1984) https://doi.org/10.1111/1523-1747.ep12261149
- Wiebel, F.J., Klose, U. & Kiefer, F. Toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in vitro: H4IIEC3- derived 5L hepatoma cells as a model system. Toxicol Lett 55, 161-169 (1991) https://doi.org/10.1016/0378-4274(91)90130-X
- Gottlicher, M. & Wiebel, F.J. 2, 3, 7, 8-Tetrachlorodibenzo- p-dioxin causes unbalanced growth in 5L rat hepatoma cells. Toxicol. Appl. Pharmacol. 111, 496- 503 (1991) https://doi.org/10.1016/0041-008X(91)90253-B
- Wolfle, D., Becker, E. & Schmutte, C. Growth stimulation of primary rat hepatocytes by 2, 3, 7, 8-tetrachlorodibenzo- p-dioxin. Cell. Biol. Toxicol. 9, 15-31 (1993) https://doi.org/10.1007/BF00755137
- Safe, S., Wang, F., Porter, W., Duan, R. & McDougal, A. Ah receptor agonists as endocrine disruptors: antiestrogenic activity and mechanisms. Toxicol. Lett. 102-103, 343-347 (1998)
- Puga, A., Maier, A. & Medvedovic, M. The transcriptional signature of dioxin in human hepatoma HepG2 cells. Biochem. Pharmacol. 60, 1129-1142 (2000) https://doi.org/10.1016/S0006-2952(00)00403-2
- Krig, S.R., Chandraratna, R.A., Chang, M.M., Wu, R. & Rice, R.H. Gene-specific TCDD suppression of RARalpha- and RXR-mediated induction of tissue transglutaminase. Toxicol. Sci. 68, 102-108 (2002) https://doi.org/10.1093/toxsci/68.1.102
- Jin, B., Kim, G., Park, D.W. & Ryu, D.Y. Microarray analysis of gene regulation in the Hepa1c1c7 cell line following exposure to the DNA methylation inhibitor 5-aza-2′-deoxycytidine and 2, 3, 7, 8-tetrachlorodibenzo- p-dioxin. Toxicol. In Vitro. 18, 659-664 (2004) https://doi.org/10.1016/j.tiv.2004.02.006
- Walker, M.K., Pollenz, R.S. & Smith, S.M. Expression of the aryl hydrocarbon receptor (AhR) and AhR nuclear translocator during chick cardiogenesis is consistent with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxininduced heart defects. Toxicol. Appl. Pharmacol. 143, 407-419 (1997) https://doi.org/10.1006/taap.1996.8068
- Gray, L.E., Wolf, C., Mann, P. & Ostby, J.S. In utero exposure to low doses of 2, 3, 7, 8-tetrachlorodibenzop- dioxin alters reproductive development of female Long Evans hooded rat offspring. Toxicol. Appl. Pharmacol. 146, 237-244 (1997) https://doi.org/10.1006/taap.1997.8222
- Martinez, J.M. et al. Differential toxicogenomic responses to 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in malignant and nonmalignant human airway epithelial cells. Toxicol. Sci. 69, 409-423 (2002) https://doi.org/10.1093/toxsci/69.2.409
- Rao, M.S., Subbarao, V., Prasad, J.D. & Scarpelli, D.G. Carcinogenicity of 2, 3, 7, 8-tetrachlorodibenzop- dioxin in the Syrian golden hamster. Carcinogenesis 9, 1677-1679 (1988) https://doi.org/10.1093/carcin/9.9.1677
- Della Porta, G., Dragani, T.A. & Sozzi, G. Carcinogenic effects of infantile and long-term 2, 3, 7, 8-tetrachlorodibenzo- p-dioxin treatment in the mouse. Tumori. 73, 99-107 (1987)
- Abbott, B.D. & Birnbaum, L.S. TCDD-induced altered expression of growth factors may have a role in producing cleft palate and enhancing the incidence of clefts after coadministration of retinoic acid and TCDD. Toxicol. Appl. Pharmacol. 106, 418-432 (1990) https://doi.org/10.1016/0041-008X(90)90337-T
- Abbott, B.D. Review of the interaction between TCDD and glucocorticoids in embryonic palate. Toxicology 105, 365-373 (1995) https://doi.org/10.1016/0300-483X(95)03234-7
- Couture, L.A., Abbott, B.D. & Birnbaum, L.S. A critical review of the developmental toxicity and teratogenicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin: recent advances toward understanding the mechanism. Teratology 42, 619-627 (1990) https://doi.org/10.1002/tera.1420420606
- Hornung, M.W., Spitsbergen, J.M. & Peterson, R.E. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin alters cardiovascular and craniofacial development and function in sac fry of rainbow trout (Oncorhynchus mykiss). Toxicol. Sci. 47, 40-51 (1999) https://doi.org/10.1093/toxsci/47.1.40
- Guiney, P.D., Smolowitz, R.M., Peterson, R.E. & Stegeman, J.J. Correlation of 2, 3, 7, 8-tetrachlorodibenzo- p-dioxin induction of cytochrome P4501A in vascular endothelium with toxicity in early life stages of lake trout. Toxicol. Appl. Pharmacol. 143, 256-273 (1997) https://doi.org/10.1006/taap.1996.8051
- Oughton, J.A. et al. Phenotypic analysis of spleen, thymus, and peripheral blood cells in aged C57B1/6 mice following long-term exposure to 2, 3, 7, 8-tetrachlorodibenzo- p-dioxin. Fundam. Appl. Toxicol. 25, 60-69 (1995) https://doi.org/10.1006/faat.1995.1040
- Bjerke, D.L. & Peterson, R.E. Reproductive toxicity of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in male rats: different effects of in utero versus lactational exposure. Toxicol. Appl. Pharmacol. 127, 241-249 (1994) https://doi.org/10.1006/taap.1994.1158
- Bjerke, D.L., Brown, T.J., MacLusky, N.J., Hochberg, R.B. & Peterson, R.E. Partial demasculinization and feminization of sex behavior in male rats by in utero and lactational exposure to 2, 3, 7, 8-tetrachlorodibenzo -p-dioxin is not associated with alterations in estrogen receptor binding or volumes of sexually differentiated brain nuclei. Toxicol. Appl. Pharmacol. 127, 258-267 (1994) https://doi.org/10.1006/taap.1994.1160
- Cummings, A.M., Metcalf, J.L. & Birnbaum, L. Promotion of endometriosis by 2, 3, 7, 8-tetrachlorodibenzo- p-dioxin in rats and mice: time-dose dependence and species comparison. Toxicol. Appl. Pharmacol. 138, 131-139 (1996) https://doi.org/10.1006/taap.1996.0106
- Gaido, K.W., Maness, S.C., Leonard, L.S. & Greenlee, W.F. 2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin-dependent regulation of transforming growth factors-alpha and - beta 2 expression in a human keratinocyte cell line involves both transcriptional and post-transcriptional control. J. Biol. Chem. 267, 24591-24595 (1992)
- Gaido, K.W. & Maness, S.C. Regulation of gene expression and acceleration of differentiation in human keratinocytes by 2, 3, 7, 8-tetrachlorodibenzo-pdioxin. Toxicol. Appl. Pharmacol. 127, 199-208 (1994) https://doi.org/10.1006/taap.1994.1154
- Gaido, K.W. & Maness, S.C. Post-transcriptional stabilization of urokinase plasminogen activator mRNA by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in a human keratinocyte cell line. Toxicol. Appl. Pharmacol. 133, 34-42 (1995) https://doi.org/10.1006/taap.1995.1124
- Choi, E.J., Toscano, D.G., Ryan, J.A., Riedel, N. & Toscano, W.A., Jr. Dioxin induces transforming growth factor-alpha in human keratinocytes. J. Biol. Chem. 266, 9591-9597 (1991)
- Kamath, A.B., Xu, H., Nagarkatti, P.S. & Nagarkatti, M. Evidence for the induction of apoptosis in thymocytes by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin in vivo. Toxicol. Appl. Pharmacol. 142, 367-377 (1997) https://doi.org/10.1006/taap.1996.8049
- Moolgavkar, S.H., Luebeck, E.G., Buchmann, A. & Bock, K.W. Quantitative analysis of enzyme-altered liver foci in rats initiated with diethylnitrosamine and promoted with 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin or 1, 2, 3, 4, 6, 7, 8-heptachlorodibenzo-p-dioxin. Toxicol. Appl. Pharmacol. 138, 31-42 (1996) https://doi.org/10.1006/taap.1996.0094
- Bunger, M.K. et al. Resistance to 2, 3, 7, 8-tetrachloroibenzo- p-dioxin toxicity and abnormal liver development in mice carrying a mutation in the nuclear localization sequence of the aryl hydrocarbon receptor. J. Biol. Chem. 278, 17767-11774. Epub 2003 Mar 5 (2003)
- Walisser, J.A., Bunger, M.K., Glover, E. & Bradfield, C.A. Gestational exposure of Ahr and Arnt hypomorphs to dioxin rescues vascular development. Proc Natl. Acad. Sci. U S A. 101, 16677-16682. Epub 2004 Nov 15 (2004) https://doi.org/10.1073/pnas.0404379101
- Boverhof, D.R. et al. Temporal and dose-dependent hepatic gene expression patterns in mice provide new insights into TCDD-Mediated hepatotoxicity. Toxicol. Sci. 85, 1048-1063. Epub 2005 Mar 30 (2005) https://doi.org/10.1093/toxsci/kfi162
- Poland, A. & Knutson, J.C. 2, 3, 7, 8-tetrachlorodibenzo -p-dioxin and related halogenated aromatic hydrocarbons: examination of the mechanism of toxicity. Annu. Rev. Pharmacol. Toxicol. 22, 517-554 (1982) https://doi.org/10.1146/annurev.pa.22.040182.002505
- Bertazzi, P.A. et al. Health effects of dioxin exposure: a 20-year mortality study. Am. J. Epidemiol. 153, 1031-1044 (2001) https://doi.org/10.1093/aje/153.11.1031
- Steenland, K., Piacitelli, L., Deddens, J., Fingerhut, M. & Chang, L.I. Cancer, heart disease, and diabetes in workers exposed to 2, 3, 7, 8-tetrachlorodibenzo-pdioxin. J. Natl. Cancer Inst. 91, 779-786 (1999) https://doi.org/10.1093/jnci/91.9.779
- Pesatori, A.C. et al. Dioxin exposure and non-malignant health effects: a mortality study. Occup. Environ. Med. 55, 126-131 (1998) https://doi.org/10.1136/oem.55.2.126
- McGregor, D.B., Partensky, C., Wilbourn, J. & Rice, J.M. An IARC evaluation of polychlorinated dibenzo -p-dioxins and polychlorinated dibenzofurans as risk factors in human carcinogenesis. Environ. Health Perspect. 106, 755-760 (1998) https://doi.org/10.2307/3433830
- Bertazzi, P.A. Long-term effects of chemical disasters. Lessons and results from Seveso. Sci. Total Environ. 106, 5-20 (1991) https://doi.org/10.1016/0048-9697(91)90016-8
- Manz, A. et al. Cancer mortality among workers in chemical plant contaminated with dioxin. Lancet. 338, 959-964 (1991) https://doi.org/10.1016/0140-6736(91)91835-I
- Kogevinas, M. et al. Cancer mortality in workers exposed to phenoxy herbicides, chlorophenols, and dioxins. An expanded and updated international cohort study. Am. J. Epidemiol. 145, 1061-1075 (1997) https://doi.org/10.1093/oxfordjournals.aje.a009069
- Hengstler, J.G., Van der Burg, B., Steinberg, P. & Oesch, F. Interspecies differences in cancer susceptibility and toxicity. Drug Metab. Rev. 31, 917-970 (1999) https://doi.org/10.1081/DMR-100101946
- Mimura, J. & Fujii-Kuriyama, Y. Functional role of AhR in the expression of toxic effects by TCDD. Biochim. Biophys. Acta. 1619, 263-268 (2003) https://doi.org/10.1016/S0304-4165(02)00485-3
- Harper, P.A., Wong, J.Y., Lam, M.S. & Okey, A.B. Polymorphisms in the human AH receptor. Chem. Biol. Interact. 141, 161-187 (2002) https://doi.org/10.1016/S0009-2797(02)00071-6
- Yueh, M.F. et al. Involvement of the xenobiotic response element (XRE) in Ah receptor-mediated induction of human UDP-glucuronosyltransferase 1A1. J. Biol. Chem. 278, 15001-15006. Epub 2003 Feb 3 (2003)
- Zhang, L., Savas, U., Alexander, D.L. & Jefcoate, C.R. Characterization of the mouse Cyp1B1 gene. Identification of an enhancer region that directs aryl hydrocarbon receptor-mediated constitutive and induced expression. J. Biol. Chem. 273, 5174-5183 (1998) https://doi.org/10.1074/jbc.273.9.5174
- Hanlon, P.R., Zheng, W., Ko, A.Y. & Jefcoate, C.R. Identification of novel TCDD-regulated genes by microarray analysis. Toxicol. Appl. Pharmacol. 202, 215-228 (2005) https://doi.org/10.1016/j.taap.2004.06.018
- Chan, W.K., Yao, G., Gu, Y.Z. & Bradfield, C.A. Cross-talk between the aryl hydrocarbon receptor and hypoxia inducible factor signaling pathways. Demonstration of competition and compensation. J. Biol. Chem. 274, 12115-12123 (1999) https://doi.org/10.1074/jbc.274.17.12115
- Wolfle, D., Marotzki, S., Dartsch, D., Schafer, W. & Marquardt, H. Induction of cyclooxygenase expression and enhancement of malignant cell transformation by 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin. Carcinogenesis. 21, 15-21 (2000) https://doi.org/10.1093/carcin/21.1.15
- Kerkvliet, N.I. Recent advances in understanding the mechanisms of TCDD immunotoxicity. Int. Immunopharmacol. 2, 277-291 (2002) https://doi.org/10.1016/S1567-5769(01)00179-5
- Lai, Z.W., Fiore, N.C., Hahn, P.J., Gasiewicz, T.A. & Silverstone, A.E. Differential effects of diethylstilbestrol and 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin on thymocyte differentiation, proliferation, and apoptosis in bcl-2 transgenic mouse fetal thymus organ culture. Toxicol. Appl. Pharmacol. 168, 15-24 (2000) https://doi.org/10.1006/taap.2000.9015
- Puga, A. et al. Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. J. Biol. Chem. 275, 2943-2950 (2000) https://doi.org/10.1074/jbc.275.4.2943
- Vaziri, C. & Faller, D.V. A benzo[a]pyrene-induced cell cycle checkpoint resulting in p53-independent G1 arrest in 3T3 fibroblasts. J. Biol. Chem. 272, 2762-2769 (1997). https://doi.org/10.1074/jbc.272.5.2762
- Tanaka, G. et al. Induction and activation of the aryl hydrocarbon receptor by IL-4 in B cells. Int. Immunol. 17, 17 (2005)
- Park, J.H. & Lee, S.W. Up-regulated expression of genes encoding Hrk and IL-3R beta subunit by TCDD in vivo and in vitro. Toxicol. Lett. 129, 1-11 (2002) https://doi.org/10.1016/S0378-4274(01)00470-2
- Davis, J.W., 2nd, Melendez, K., Salas, V.M., Lauer, F.T. & Burchiel, S.W. 2, 3, 7, 8-Tetrachlorodibenzop- dioxin (TCDD) inhibits growth factor withdrawalinduced apoptosis in the human mammary epithelial cell line, MCF-10A. Carcinogenesis. 21, 881-886 (2000) https://doi.org/10.1093/carcin/21.5.881
- Afshari, C.A., Nuwaysir, E.F. & Barrett, J.C. Application of complementary DNA microarray technology to carcinogen identification, toxicology, and drug safety evaluation. Cancer Res. 59, 4759-4760 (1999)
- Shalon, D., Smith, S.J. & Brown, P.O. A DNA microarray system for analyzing complex DNA samples using two-color fluorescent probe hybridization. Genome Res. 6, 639-645 (1996) https://doi.org/10.1101/gr.6.7.639
- Lipshutz, R.J., Fodor, S.P., Gingeras, T.R. & Lockhart, D.J. High density synthetic oligonucleotide arrays. Nat. Genet. 21, 20-24. (1999) https://doi.org/10.1038/4447
- Hacia, J.G. Resequencing and mutational analysis using oligonucleotide microarrays. Nat. Genet. 21, 42- 47 (1999) https://doi.org/10.1038/4469
- Orphanides, G. Toxicogenomics: challenges and opportunities. Toxicol Lett 140-141, 145-148 (2003) https://doi.org/10.1016/S0378-4274(02)00500-3
- Huang, Q. et al. Gene expression profiling reveals multiple toxicity endpoints induced by hepatotoxicants. Mutat. Res. 549, 147-167 (2004) https://doi.org/10.1016/j.mrfmmm.2003.12.020