Genomics & Informatics
- 제3권4호
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- Pages.166-171
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- 2005
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- 1598-866X(pISSN)
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- 2234-0742(eISSN)
A Cotwin Control Study of Smoking and Risk Factors of Metabolic Syndrome
- Sung, Jooh-On (Department of Preventive Medicine, Kangwon National University College of Medicine) ;
- Cho, Sung-Il (Department of Epidemiology and Biostatistics, Seoul National University School of Public Health) ;
- Choi, Ji-Sook (Department of Family Medicine, SungKyunKwan University School of Medicine) ;
- Song, Yun-Mi (Department of Family Medicine, SungKyunKwan University School of Medicine) ;
- Lee, Ka-Young (Department of Family Medicine, Inje University College of Medicine) ;
- Choi, Eun-Young (Department of Family Medicine, Dankook University College of Medicine) ;
- Ha, Mi-Na (Department of Preventive Medicine, Dankook University College of Medicine) ;
- Kim, Yeon-Ju (Department of Preventive Medicine, Seoul National University College of Medicine) ;
- Shin, Eun-Kyung (Department of Epidemiology and Biostatistics, Seoul National University School of Public Health)
- 발행 : 2005.12.01
초록
Background: Smoking effects are relatively well-documented, especially on cancers and cardiovascular diseases. However, the direction and magnitude of association between smoking and obesity remain unclear. Conflicting results so far are thought to stem from the multiple confounding structure of smoking and other obesogenic life style characteristics. Methods: Cotwin control study is a genomic epidemiology design, in which the other twin (=cotwin) serves as a control of the twin. Cotwin control study, discordant for smoking habits can provide powerful evidence of association between smoking and obesity by completely matching genomic information, intrauterine environment, and almost all environmental factors. We selected 3,697 like-sex twin pairs (2,762 male and 935 female pairs) out of 63,666 pairs of adult twins in the existing Korea Twin and Family Register, whose smoking habits are discordant. We used the information of obesity as body mass index (BMI,