Inhibitory Effect of Gamisaenghyeolyunbueum on Mast Cell-Mediated Allergic Inflammatory Reactions

  • Choi Cheol-Ho (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Hur Jong-Chan (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim Hoon (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Cho Young-Kee (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon Mi-Hyun (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Baek Dong-Gi (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Kim Dong-Woung (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Moon Goo (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University) ;
  • Won Jin-Hee (Department of Internal Medicine, College of Oriental Medicine, Wonkwang University)
  • Published : 2005.10.01

Abstract

Gamisaenghyeolyunbueum (GSYE) is a traditional Oriental herbal medicine prescription, which has been used for the treatment of various allergic disorders, atopic dermatitis, extravasated bleeding from skin, especially skin related disease. The author investigated the effects of GSYE on mast cell-mediated allergic inflammatory reactions. GSYE dose-dependently (0.01-1 g/kg) inhibited compound 48180-induced systemic anaphylactic shock and ear swelling response. The inhibitory effect of GSYE on the histamine release from rat peritoneal mast cells induced by compound 48f80 reveals significantly (p<0.05) at concentrations ranging from 0.01 to 1 mg/ml in a dose-dependent manner. GSYE also inhibited the passive cutaneous anaphylaxis(PCA) by oral administration at 1 g/kg. In addition, GSYE dose-dependently (0.01-1 g/kg) inhibited the phorbol 12-myristate 13-acetate(PMA) and A23187-induced tumor necrosis $factor-{\alpha}$ secretion from human mast cell line HMC-1 cells. These results indicate that GSYE may be a beneficial applicability in the allergic-related diseases.

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