Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effects of SoPung-Tang extract on Hypertension and Common Carotid Artery

소풍탕(疎風湯)이 고혈압과 동맥혈관에 미치는 영향

  • Choe Seok-Jin (Department of Physiology, College of Oriental Medicine, Semyung University) ;
  • Kim Hee-Taek (Department of Ophthamology and Otolarynology, College of Oriental Medicine, Semyung University) ;
  • Jo Hak-Jun (Department of Korean Medical Classics, College of Oriental Medicine, Semyung University) ;
  • Kim Ho-Hyun (Department of Physiology, College of Oriental Medicine, Semyung University)
  • 최석진 (세명대학교 한의과대학 생리학교실) ;
  • 김희택 (세명대학교 한의과대학 안이비인후과학교실) ;
  • 조학준 (세명대학교 한의과대학 원전의사학교실) ;
  • 김호현 (세명대학교 한의과대학 생리학교실)
  • Published : 2005.12.01
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Abstract

This study was undertaken to define the effect of SoPung-Tang extract on hypertension in spontaneous hypertensive rat and norepinephrine- induced arterial contraction in rabbit. In order to investigate the effect of SoPung-Tang extract on contracted rabbit carotid arterial strips, transverse strips with intact or damaged endothelium were used for the experiment using organ bath. To analyze the mechanism of SoPung-Tang extract-induced relaxation, SoPung-Tang extract infused into contracted arterial strips induced by norepinephrine after treatment of indomethacin, Nu-nitro-L-arginine, methylene blue or tetraethylammonium chloride. Blood pressure was significantly decreased five days after administration of SoPung-Tang extract. SoPung-Tang extract relax arterial strip with endothelium contracted by norepinephrine, but in the strips without endothelium, SoPung-Tang extract- induced relaxation was significantly inhibited. SoPung-Tang relax arterial strip contracted by norepinephrine, but in the strips contracted by high $K^+$, SoPung-Tang extract-induced relaxation was significantly inhibited. The endothelium-dependent relaxation induced by SoPung-Tang extract was decreased by the pre-treatment of $N{\omega}$-nitro-L-arginine or methylene blue, but it was not observed in the strips pre-treated with indomethacin or tetraethylammonium chloride. When $Ca^{2+}$ was applied, the strips which were contracted by norepinephrine in a $Ca^{2+}$-free solution, arterial contraction was increased. But pre-treatment of SoPung-Tang extract inhibited contractile response to $Ca^{2+}$. We suggest that SoPung-Tang could be applied effectively for hypertension and may suppress influx of extra-cellular $Ca^{2+}$ through the formation of nitric oxide in the vascular endothelial cells.

Keywords

References

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