Journal of Physiology & Pathology in Korean Medicine (동의생리병리학회지)

The Physiological Society of Korean Medicine and The Society of Pathology in Korean Medicine (대한동의생리학회·한의병리학회)
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Effect of Brassica rapa L. extracts and ${\beta}-sitosterol$ on hyperlipidemic rats

순무와 ${\beta}-sitosterol$의 고지혈증 억제에 대한 연구

  • Rhee Yun-Hee (Department of Oncology, Graduate School of East-West Medical Science, KyungHee University) ;
  • Lee Eun-Ok (Department of Oncology, Graduate School of East-West Medical Science, KyungHee University) ;
  • Park Soo-Young (Department of Oncology, Graduate School of East-West Medical Science, KyungHee University) ;
  • Lee Hyo-Jung (Department of Oncology, Graduate School of East-West Medical Science, KyungHee University) ;
  • Yoon Byong-Su (Department of Biology, Kyonggi University) ;
  • Kim Jung-Hyo (Chosun Nursing College) ;
  • Kim Sung-Hoon (Department of Oncology, Graduate School of East-West Medical Science, KyungHee University)
  • 이연희 (경희대학교 동서의학대학원 종양학교실) ;
  • 이은옥 (경희대학교 동서의학대학원 종양학교실) ;
  • 박수영 (경희대학교 동서의학대학원 종양학교실) ;
  • 이효정 (경희대학교 동서의학대학원 종양학교실) ;
  • 윤병수 (경기대학교 자연과학대학 분자유전학 실험실) ;
  • 김정효 (조선간호대학) ;
  • 김성훈 (경희대학교 동서의학대학원 종양학교실)
  • Published : 2005.12.01
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Abstract

To evaluate the anti-hyperlipidemic effect of Brassica rapa L. and its major compound, $\beta$-sitosterol, the present study was undertaken, hypercholesterolemia was induced in rats with poloxamer-407, Triton WR-1339, 30% corn oil high cholesterol diet. The ethanol extract of Brassica rapa L. significantly decreased total cholesterol (TC), phospholipid, triglyceride at doses of 200 mg/kg, and $\beta$-sitosterol significantly exerted anti-hyperlipidemic activity at a dose of 15 mg/kg in rats with hyperlipidemia. Taken together, Brassica rapa L. and $\beta$-sitosterol can be useful agents for the prevention or treatment of hyperlipidemia.

Keywords

References

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