Journal of Biomedical Engineering Research (대한의용생체공학회:의공학회지)

The Korean Society of Medical and Biological Engineering (대한의용생체공학회)
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An fMRI Study of Cognitive Function during Hyperoxia

  • Chung Soon-Cheol (Department of Biomedical Engineering, College of Medicine, Konkuk University) ;
  • Kim Ik-Hyeon (Department of Biomedical Engineering, College of Medicine, Konkuk University) ;
  • Tack Gye-Rae (Department of Biomedical Engineering, College of Medicine, Konkuk University) ;
  • Lee Soo Yeol (Graduate School of East-West Medical Science, Kyunghee University) ;
  • Sohn Jin-Hun (Department of Psychology, Institute for Brain Research, Chungnam National University)
  • Published : 2005.02.01
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Abstract

This study aimed to investigate the hypothesis that administration of the air with 30% oxygen compared with normal air (21% oxygen) enhances cognitive functioning through increased activation in the brain. Seventeen college students (right­handed, average age of 24.3) were selected as subjects for this study. An oxygen supply equipment that provides 21% and 30% oxygen at a constant rate of 8L/min was developed. In order to measure the performance level of visuospatial and verbal cognition, two psychological tests were developed. The experiment consisted of two runs, one for cognition task with normal air (21% oxygen) and the other for cognition task with hyperoxic air (30% oxygen). Visuospatial and verbal tasks were presented while brain images were scanned by a 3T fMRI system using the single-shot EPI method. The results showed that there was an improvement in performance and also increased activation in several brain areas in the higher oxygen condition. These results suggest that while performing cognitive tasks, high concentrations of oxygen administration make oxygen administration sufficient, thus making neural network activate more, and the ability to perform cognitive tasks increase.

Keywords

References

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