한국전문물리치료학회지 (Physical Therapy Korea)

  • 제12권3호
  • /
  • Pages.11-21
  • /
  • 2005
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  • 1225-8962(pISSN)
  • /
  • 2287-982X(eISSN)
한국전문물리치료학회 (Korean Research Society of Physical Therapy)
권호 표지

수영 훈련이 뇌허혈 유발 흰쥐의 해마 치아이랑에서 뇌신경생성과 기능적 능력에 미치는 영향

The Effects of Swim Training on Neurogenesis in the Hippocampal Dentate Gyrus and Functional Ability After Focal Ischemic Stroke in Rats

  • 김호성 (일맥의료재단 인애가 한방병원) ;
  • 김덕호 (일맥의료재단 인애가 한방병원) ;
  • 이정필 (한국체육대학교 대학원 스포츠의학 연구실) ;
  • 김영주 (한국체육대학교 대학원 스포츠의학 연구실) ;
  • 신영오 (한국체육대학교 대학원 스포츠의학 연구실) ;
  • 김상훈 (한국체육대학교 대학원 스포츠의학 연구실) ;
  • 권기욱 (한국체육대학교 대학원 스포츠의학 연구실) ;
  • 오재근 (한국체육대학교 대학원 스포츠의학 연구실)
  • Kim, Ho-Sung (Inega Oriental Medical Hospital, Ilmaek Medical Group) ;
  • Kim, Deuk-Ho (Inega Oriental Medical Hospital, Ilmaek Medical Group) ;
  • Lee, Jeong-Pil (Dept. of Sports Medicine, The Graduate School, Korea National Sport University) ;
  • Kim, Young-Joo (Dept. of Sports Medicine, The Graduate School, Korea National Sport University) ;
  • Shin, Young-Oh (Dept. of Sports Medicine, The Graduate School, Korea National Sport University) ;
  • Kim, Sang-Hoon (Dept. of Sports Medicine, The Graduate School, Korea National Sport University) ;
  • Kwon, Ki-Wook (Dept. of Sports Medicine, The Graduate School, Korea National Sport University) ;
  • Oh, Jae-Keun (Dept. of Sports Medicine, The Graduate School, Korea National Sport University)
  • 투고 : 2005.04.17
  • 심사 : 2005.07.25
  • 발행 : 2005.09.17
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초록

The present study was aimed at investigating the effect of swimming training on brain function after focal cerebral ischemia in rats. Therefore, this study was examined on neurogenesis in dentate gyrus of hippocampus using 5-bromo-2'-deoxyuridine (BrdU) to label proliferating cells and assessed the neurological response following focal cerebral ischemia in rats using neurological motor behavioral test. In an observer-blinded fashion, twenty male Sprague-Dawley (280~310 g, 7 weeks old) rats were divided into four groups: MCAO plus swimming group (ME, $n_1$=5), MCAO plus control group (MC, $n_2$=5), SHAM plus swimming group (SE, $n_3$=5), SHAM plus control group (SC, $n_4$=5). The results of this study were as follows: 1) The limb placing time before and after swimming in the ME group were significantly longer than the MC group (p<.05), the SE group were significantly longer than the SC group (p<.01). 2) The balance beam scores before and after swimming in the ME group was higher than the SE group, the MC group was higher than the SC group but was not significantly different (p>.001). 3) The foot fault index before and after swimming training in ME group was significantly lower (i.e., improved) than the MC group (p<.001) and the SE group (p<.001), the SE group was significantly lower (i.e., improved) than the SC group (p<.001). 4) The mean number of BrdU-positive cells in the dentate gyrus in the ME group was significantly higher than the MC group (p<.001) and the SE group (p<.01). The MC group and the SE group was significantly higher than the SC group (p<.001). 5) There was significantly correlation between limb placing time and number of BrdU-positive cells on swimming training, there was positive correlation (r=.807, p<.0001) and between foot fault index and BrdU-positive cells number, there was negative correlation (r=-.503, p<.05). However, between balance beam scores and BrdU-positive cells number, there was no correlation. In conclusion, the present study demonstrates that the role of swimming training improves behavioral motor function probably by enhancing cell proliferation in that hippocampus. This study provides a model for investigating the stroke rehabilitation that underlies neurogenesis and functional ability.

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