Journal of Microbiology and Biotechnology

  • 제15권1호
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  • Pages.216-220
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  • 2005
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  • 1017-7825(pISSN)
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  • 1738-8872(eISSN)
한국미생물·생명공학회 (The Korean Society for Microbiology and Biotechnology)
권호 표지

Biological Characterization of Periconicins, Bioactive Secondary Metabolites, Produced by Periconia sp. OBW-15

  • SHIN, DONG-SUN (Natural Products Research Institute, College of Pharmacy, Seoul National University) ;
  • OH, MI-NA (Graduate School of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University) ;
  • YANG, HYEONG-CHEOL (Department of Dental Biomaterials Science, College of Dentistry, Seoul National University) ;
  • OH, KI-BONG (Natural Products Research Institute, College of Pharmacy, Seoul National University, Graduate School of Agricultural Biotechnology, College of Agriculture and Life Sciences, Seoul National University)
  • 발행 : 2005.02.01
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초록

Periconicin A and B, two new fusicoccane diterpenes originally isolated from the cultures of endophytic fungus Periconia sp. OBW-15, were tested by several biological assays. Periconicin A was consistently more active than periconicin B. In an antifungal activity assay, periconicin A showed potent inhibitory activity against the agents of human mycoses, including Candida albicans, Trichophyton mentagrophytes, and T. rubrum, with minimum inhibitory concentration (MIC) in the range of 3.12- 6.25 $\mug$ /ml. In a plant growth regulatory activity assay, periconicins inhibited hypocotyl elongation and root growth of Brassica campestris L. and Raphanus sativus L. At concentrations below 1 μg/ml, however, both compounds accelerated root growth by 110- 135%. From these results, it is apparent that a methyl group positioned in a cyclopentane ring may play an important role in plant and fungal growth inhibitory activity.

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