Pediatric Infection and Vaccine
- 제12권1호
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- Pages.75-85
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- 2005
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- 2384-1079(pISSN)
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- 2384-1087(eISSN)
발열을 동반한 호중구감소 상태의 급성백혈병 환아에서 경험적 항진균제로 투여한 Amphotericin B와 Itraconazole의 효과와 이상 반응 비교
Comparison of Amphotericin B and Itraconazole as Empirical Antifungal Therapy in Children with Acute Leukemia with Neutropenic Fever
- 이상윤 (충남대학교 의과대학 소아과학교실) ;
- 박종선 (충남대학교 의과대학 약리학교실) ;
- 김선영 (충남대학교 의과대학 소아과학교실) ;
- 양금진 (충남대학교 의과대학 약리학교실) ;
- 박경덕 (충남대학교 의과대학 소아과학교실) ;
- 김학기 (가톨릭대학교 의과대학 소아과학교실)
- Lee, Sang-Yun (Departments of Pediatrics, College of Medicine, Chungnam National University) ;
- Park, Jong-Sun (Departments of Pharmacology, College of Medicine, Chungnam National University) ;
- Kim, Sun-Young (Departments of Pediatrics, College of Medicine, Chungnam National University) ;
- Yang, Keum-Jin (Departments of Pharmacology, College of Medicine, Chungnam National University) ;
- Park, Kyung-Deok (Departments of Pediatrics, College of Medicine, Chungnam National University) ;
- Kim, Hack-Ki (Department of Pediatrics, College of Medicine, The Catholic University)
- 발행 : 2005.05.31
초록
목 적 : 혈액종양 환아의 항암요법 후 발생한 호중구감소증 상태에서, 진균 감염은 높은 치명률을 가지는 것으로 알려져 있다. 진균 감염에 대한 경험적 항진균제로 주로 사용되는 ABV는 염증성 사이토카인인 IL-
Purpose : Fungal infection is one of the important causes of morbidity and mortality in patients with hematologic malignancies. Amphotericin B(ABV) and itraconazole(ITZA) have been used as the standard empirical antifungal therapy in neutropenic patients with acute leukemia who have persistent fever that does not respond to antibiotic therapy. ABV is an antifungal drug associated with side effects such as fever and chills, symptoms which may be mediated by pro-inflammatory cytokines such as interleukin-