Journal of The Korean Society of Clinical Toxicology (대한임상독성학회지)
- Volume 3 Issue 2
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- Pages.86-92
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- 2005
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- 1738-1320(pISSN)
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- 2508-6332(eISSN)
Survival Curve Analysis in Patients with Severe Organophosphate Poisoning
중증 급성 유기인계 중독환자의 생존분석
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Lee, Mi-Jin
(Department of Emergency Medicine, College of Medicine, The Catholic University of Korea) ;
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Park, Kyu-Nam
(Department of Emergency Medicine, College of Medicine, The Catholic University of Korea) ;
- Lee, Won-Jae (Department of Emergency Medicine, College of Medicine, The Catholic University of Korea)
- Published : 2005.12.01
Abstract
Purpose: The main cause of death due to acute organophosphate (OP) poisoning is believed acute respiratory failure caused by cholinergic reactions. Recently, advances in respiratory and intensive care make it possible to maintain the respiratory function of patients with OP poisoning, but the mortality rates remain high. The present study clarified the hemodynamics of patients with acute lethal OP poisoning. The purpose of this study was to analyse the outcomes and predictors of mortality in patients with acute OP poisoning requiring intensive care. Methods: We reviewed medical and intensive care records of patients with acute OP poisoning admitted to emergency department and ICU between March 1998 and Aug 2005. We collected patient information regarding poisoning, clinical, and demographic features. Results: During the study period, 67 subjects treated with intensive care and ventilator management in addition to gastric decontamination standard therapy with atropine and 2-PAM. Of 67 patients, 13 died. Kaplan-Meier survival analysis demonstrated a steep decline in the cumulative survival to