관상동맥조영술상 정상소견을 보인 환자에서 전산화단층촬영술(CT)를 이용한 감쇠보정이 심근관류 SPECT의 판독에 미치는 영향

The Effect of Attenuation Correction with CT on the Interpretation of Myocardial Perfusion SPECT: in Patients with Normal Coronary Angiogram

  • 천경아 (영남대학교의료원 핵의학과) ;
  • 조인호 (영남대학교의료원 핵의학과) ;
  • 원규장 (영남대학교의료원 핵의학과) ;
  • 이형우 (영남대학교의료원 핵의학과) ;
  • 홍그루 (영남대학교의료원 순환기 내과) ;
  • 신동구 (영남대학교의료원 순환기 내과) ;
  • 김영조 (영남대학교의료원 순환기 내과) ;
  • 심봉섭 (영남대학교의료원 순환기 내과)
  • Chun, Kyung-Ah (Department of Nuclear Medicine, Yeungnam University Hospital) ;
  • Cho, Ihn-Ho (Department of Nuclear Medicine, Yeungnam University Hospital) ;
  • Won, Kyu-Chang (Department of Nuclear Medicine, Yeungnam University Hospital) ;
  • Lee, Hyung-Woo (Department of Nuclear Medicine, Yeungnam University Hospital) ;
  • Hong, Geu-Ru (Department of Internal Medicine, Yeungnam University Hospital) ;
  • Shin, Dong-Gu (Department of Internal Medicine, Yeungnam University Hospital) ;
  • Kim, Young-Jo (Department of Internal Medicine, Yeungnam University Hospital) ;
  • Shim, Bong-Sup (Department of Internal Medicine, Yeungnam University Hospital)
  • 발행 : 2005.08.31

초록

목적: 심근관류 스펙트 검사에서 감쇠의 영향을 보정하기 위해 여러 가지 방법들이 사용되어 왔다. 본 연구는 CT를 이용한 감쇠보정이 관상동맥조영술이 정상인 환자들을 대상으로 하였을 때 어떠한 영향을 주는지 알아보고 기존의 감쇠보정방법들과 차이가 있는지를 알아보고자 하였다. 대상 및 방법: 관상동맥질환이 의심되어 심근 SPECT/CT를 시행한 환자들 중 관상동맥조영술상 정상소견을 보인 25명에서, Pryor 등의 방법으로 관상동맥질환의 위험도가 5.0% 미만인 15명의 환자를 대상으로 하였다. (남 6, 여 9, 평균연령 $58{\pm}8$세). CT가 장착된 Millennium VG (GE) 카메라로 감쇠보정을 하였으며, 영상의 판독은 육안분석과 극성지도를 이용한 정량적 분석을 시행하였다. 정량적 분석의 경우 극성지도 상에서 각 심근벽의 섭취율(최대 섭취율에 대한 %)을 구하여 감쇠보정을 하지 않은 영상과 감쇠보정을 한 영상을 비교하였다. 결과: 육안분석에서 감쇠보정을 한 경우 하벽의 섭취는 증가한 반면, 전벽과 심첨부 및 격벽의 섭취는 감소하였다. 간에서의 섭취도 감쇠보정을 한 경우에 증가하였다. 정량분석에서는 심첨부의 경우 감쇠보정 후 섭취율이 감소하였고, 하벽의 경우 증가하였다. 하벽의 경우 감쇠보정을 하여 판독에 도움을 받을 수 있었고, 반면 전벽이나 심첨부의 경우 감쇠보정 후 판독에 어려움이 있었다. 결론: 하벽의 경우 CT를 이용한 감쇠보정을 한 경우 판독에 도움이 되었으며, 감쇠보정전 영상이 정상인 경우 심첨부나 전벽등의 판독시는 주의가 필요하다.

Purpose: There has been many reports for the effect of attenuation correction on myocardial perfusion SPECT. We studied the effect of attenuation correction with CT (computed tomography) in patients with normal coronary angiography. Materials and Methods: Fifteen patients with normal coronary artery on angiography and low likelihood of coronary artery disease were enrolled in this study (male: 6, female: 9, mean age: $58{\pm}8$ year). Myocardial perfusion SPECT was done with Millennium VG with Hawkeye device (GE, SPECT/CT camera). A visual analysis and polar map quantification (Emory tool box) was performed. In quantitative analysis, percent uptake of each myocardial wall on polar map (percent of maximal uptake) was compared between non-corrected (NC) and corrected (AC) images. Results: Visual analysis showed AC images led to an increase of uptake in the inferior wall, but decrease of uptake in the anterior wall, apex and septum. liver activity is also increased in AC images. In quantitative analysis, the percent uptake is decreased in the anterior wall, apex and septum, but increased in the inferior wall. It is helpful to interpret the images in the inferior wall after AC, but difficult in the apex and anterior wall after AC. Conclusion: AC is helpful in the inferior wall. But in the apex or anterior wall, AC must be carefully applied to normal perfused myocardium.

키워드

참고문헌

  1. DePuey EG. How to detect and avoid myocardial perfusion SPECT artifacts. J Nucl Med 1994;35:699-702
  2. Slart R, Que T, Veldhuisen D, Poot L, Blanksma P, Piers A. et al. Effect of attenuation correction on the interpretation of $^{99m}$TC-Sestamibi myocardial perfusion scintigraphy: the impact of 1 year's experience. Eur J Nucl Med Mol Imaging 2003;30:1505-9. https://doi.org/10.1007/s00259-003-1265-3
  3. Ficaro EP, Fessler JA, Shreve PD, Kritzman JN, Rose PA, Corbett JR. Simultaneous transmission/emission myocardial perfusion tomography. Diagnostic accuracy of attenuation-corrected Tc-99m Sestamibi single photon emission computed tomography. Circulation 1996;93:463-73 https://doi.org/10.1161/01.CIR.93.3.463
  4. Hendel RC, Berman DS, Cullum SJ, Follansbee W, Heller GV, Kiat H, et al. Multicenter clinical trial to evaluate the efficacy of correction for photon attenuation and scatter in SPECT myocardial perfusion imaging. Circulation 1999;99:2742-9 https://doi.org/10.1161/01.CIR.99.21.2742
  5. Lee DS, So Y, Cheon GJ, Kim KM, Lee MM, Chung JK, Lee MC. Limited incremental diagnostic values of attenuation-noncorrected gating and ungated attenuation correction to rest/stress myocardial perfusion SPECT in patients with an intermediate likelihood of coronary artery disease. J Nucl Med. 2000;41:852-9
  6. Hendel RC, Corbett JR, Cullum SJ, DePuey G, Garcia EV, Bateman TM. The value and practice of attenuation correction for myocardial perfusion SPECT imaging: a joint position statement from the American society of nuclear cardiology and the society of nuclear medicine. J Nucl Med 2002;43:273-80
  7. Banzo I, Pena F, Allende R, Quirce R, Carril J. Prospective clinical comparison of non-corrected and attenuation- and scatter-corrected myocardial perfusion SPECT in patients with suspicion of coronary artery disease. Nuel Med Commun 2003;24:995-1002 https://doi.org/10.1097/00006231-200309000-00008
  8. Hwang KH, Lee DS, Paeng JC, Lee MM, Chung JK, Lee Me. Effect of attenuation correction, scatter correction and resolution recovery on diagnostic performance of quantitative myocardial SPECT for coronary artery disease. Korean J Nucl Med 2002;36: 288-98
  9. Fricke E, Fricke H, Weise R, Kammeier A, Hagedorn R, Lotz N, et al. Attenuation correction of myocardial SPECT perfusion images with low-dose CT: Evaluation of the method by comparison with perfusion PET. J Nucl Med 2005;46:736-44
  10. Pryor DB, Harrell FE Jr, Lee KL, Califf RM, Rosati RA. Estimating the likelihood of significant coronary artery disease. Am J Med 1983;75:771-80 https://doi.org/10.1016/0002-9343(83)90406-0
  11. Savi A, Rossetti C, Gilardi MC, Landoni C, Rizzo G, Ippolito M, et al. Correction measured by attenuation in tomographic heart studies with single photon emission with thallium 201. Comparison with positron-emission tomographic studies with single photon emission studies with ammonium marked with nitrogen. Radiol Med (Torino) 1999;98:36-42