The Korean Journal of Nuclear Medicine (대한핵의학회지)

The Korean Society of Nuclear Medicine (대한핵의학회)
권호 표지

Radiopharmaceuticals of Cardiac SPECT Imaging

심장스펙트 영상에 사용되는 방사성의약품

  • Chung, Yong-An (Department of Nuclear Medicine, The College of Medicine, The Catholic University of Korea)
  • 정용안 (가톨릭대학교 의과대학 방사선과학교실 핵의학과)
  • Published : 2005.04.30
Download PDF
⟨ Previous Next ⟩

Abstract

Ever since it was first introduced as a method of scintigraphically measuring regional myocardial perfusion, myocardial perfusion study has been widely used in patients diagnosed or suspected with coronary artery diseases, and continuously improved upon. In addition to the technological enhancement of nuclear medicine equipments, the innovation of radiopharmaceuticals used in the cardiac exams were important contributors to such improvement. Besides the cardiac perfusion studies, new radiopharmaceuticals that visualize fat metabolism or receptors of the sympathetic nervous system have successfully been applied to clinical practice. More information can be collected before diagnosing coronary vascular disease, evaluating the patient's condition, or assessing therapeutic effects. In this review article, the clinical efficacy and characteristics of radiopharmaceutical products tailored for cardiac SPECT that are commonly used in Korea currently, plus the ones not being used yet but have proven value are briefly described.

Keywords

References

  1. Sapirstein LA. Regional Blood flow by fractional distribution of indicators. Am J Physiol 1958;193:161-6
  2. Zimmer L, McCall D, D'Addabbo L, et al. Kinetics and characteristics of thallium exchange in cultured cells. Circulation 1979;59:138-43
  3. Weich HF, Strauss HW, Pitt B. Extraction of Tl-201 by the myocardium. Circulation 1977;56:188-92 https://doi.org/10.1161/01.CIR.56.2.188
  4. Krahwinkel W, Herzog H, Feinendegen LE. Pharmacokinetics of thallium-201 in normal indivisuals after routine myocardial scintigraphy. J Nucl Med 1988;29:1582-6
  5. Deutsch E, Bushong W, Glavan KA, et al. Heart imaging with cationic complexes of technetium. Science 1981;214:85-6 https://doi.org/10.1126/science.6897930
  6. Jones AG, Davison A, Abram S, et al. Biological studies of a new class of technetium complexes: the hexakis (alkylisonitrile) technetium (I) cations. Int J Nucl Med Biol 1984;11:225-34 https://doi.org/10.1016/0047-0740(84)90004-4
  7. Piwnica-Worms D, Kronauge JF, Chiu ML. Uptake and retention of hexakis (2-methyoxyisobutyl-isonitrile) technetium (I) in cultured chick myocardial cells. Mitochondrial and plasma membrane potential dependence. Circulation 1990;82:1826-38 https://doi.org/10.1161/01.CIR.82.5.1826
  8. Sinusas AJ, Beller GA, Smith WH, et al. Quantitative planar imaging with technetium-99m methoxy isobutyl isonitrile: comparison of uptake patterns with thallium-201. J Nucl Med 1989;30:1456-63
  9. Verani MS, Jeroudi MO, Mahmarian JJ, et al. Quantification of myocardial infarction during coronary occlusion and myocardial salvage after reperfusion using cardiac imaging with technetium-99m hexakis 2-methoxyisobutyl isonitrile. J Am Coll Cardiol 1988;12: 1573-81 https://doi.org/10.1016/S0735-1097(88)80028-7
  10. Wackers FJ, Berman DS, Maddahi J, et al. Technetium-99m hexakis-2-methoxyisobutyl isonitrile: human biodistribution, dosimetry, safety and preliminary comparison to thallium-201 for myocardial perfusion imaging. J Nucl Med 1989;30:310-11
  11. Sinusas AJ, Shi QX, Saltzberg MT, et al. Technetium-99m tetrofosmin to assess myocardial blood flow: experimental validation in an intact canine model of ischemia. J Nucl Med 1994;35:664-71
  12. Platts EA, North TL, Pickett RD, et al. Mechanism of uptake of technetium-tetrofosmin. I: uptake into isolated adult rat ventricular monocytes and subcellular localization. J Nucl Cardiol 1995;2: 317-26 https://doi.org/10.1016/S1071-3581(05)80076-5
  13. Younes A, Songadele JA, Maublant J, et al. Mechanism of uptake of technetium-tetrofosmin. II: uptake into isolated adult rat heart mitochondria. J Nucl Cardiol 1995;2:327-33 https://doi.org/10.1016/S1071-3581(05)80077-7
  14. Taillefer R. Technetium-99m-N-NOEt. In: Taillefer R, Tamaki N, eds. New radiotracers in cardiac imaging: principles and applications. Stamford, CT: Appleton Lange, 1999:113-24
  15. Pasqualini R, Comazzi V, Bellande E, et al. A new efficient method for the preparation of Tc-99m radiopharmaceuticals containing the Tc=N multiple bond. Appl Radiat Isot 1992;43:1329-33 https://doi.org/10.1016/0883-2889(92)90004-X
  16. Glover DK, Ruiz M, Calnon DA, et al. Favorable first-pass myocardial extraction fraction for technetium-99m N-NOEt: Implications for pharmacologic stress imaging. J Nucl Med 1997;38:65(abst)
  17. Dahlberg ST, Gilmore MP, Flood M, et al. Extraction of technetium-99m-N-NOEt in the isolated rabbit heart. Circulation 1994;90:I-368(abst)
  18. Riou L, Ghezzi C, Vanzeto G, et al. Verapamil does not inhibit (99m)TcN-NOET uptake in situ in normal or ischemic myocardium. J Nucl Med 2003;44:981-7
  19. Ghezzi C, Fagret D, Arvieux CC, et al. Myocardial kinetics of TcN-NOET: a neutral lipophilic complex tracer of regional myocardial blood flow. J Nucl Med 1995;36:1069-77
  20. Vanzetto G, Calnon DA, Ruiz M, et al. Myocardial uptake of 99Tc-NOET in dogs with reperfused acute myocardial infarction: comparison to Tl-201. J Nucl Cardiol 1997;4:S21(abst)
  21. Johnson G, Nguyen KN, Liu Z, et al. Planar imaging of Tc-99m labeled (bis(N-ethoxy, N-ethyl dithiocarbamato) nitride technetium (V)) can detect resting ischemia. J Nucl Cardiol 1997;4:217-25 https://doi.org/10.1016/S1071-3581(97)90082-9
  22. Fujibayashi Y, Nohara R, Hosokawa R, et al. Metabolism and kinetics of iodine 123-BMIPP in canine myocardium. J Ncul Med 1996;37:757-61
  23. Noriyasu K, Mabuchi M, Kuge Y, et al. Serial changes in BMIPP uptake in relation to thallium in the rat myocardium after ischemia. Eur J Nucl Med Mol Imaging 2003;30:1644-50 https://doi.org/10.1007/s00259-003-1305-z
  24. Alman KC, Lahiri A. I-123 MIBG scintigraphy in idiopathic dilated cardiomyopathy: where next? J Nucl Cardiol 2002;9:127-30 https://doi.org/10.1067/mnc.2002.121175
  25. Momose M, Kobayashi H, Iguchi N, et al. Comparison of parameters of I-123 MIBG scintigraphy for predicting prognosis in patients with dilated cardiomyopathy. Nucl Med Commun 1999;20:529-35 https://doi.org/10.1097/00006231-199906000-00007