Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Systemic Availability and Pharmacokinetics of Surfactin, a Lipopeptide Produced by Bacillus subtilis BC1212 in Rats

  • Lim Jong-Hwan (B&C Biopharm) ;
  • Kim Myoung-Seok (College of Veterinary Medicine, Chungnam National University) ;
  • Park Byung-Kwon (College of Veterinary Medicine, Chungnam National University) ;
  • Hwang Youn-Hwan (College of Veterinary Medicine, Chungnam National University) ;
  • Hwang Mi-Hyun (College of Veterinary Medicine, Kyoungbuk National University) ;
  • Park Seung-Chun (College of Veterinary Medicine, Kyoungbuk National University) ;
  • Yun Hyo-In (College of Veterinary Medicine, Chungnam National University)
  • Published : 2005.12.01
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Abstract

The aim of the present study was to evaluate systemic bioavailability of surfactin and to determine its pharmacokinetic profiles. The stability of surfactin to pH, temperature and protease was evaluated. Surfactin was resistant to high temperature, a wide range of pH and the action of hydrolytic enzymes. The pharmacokinetic natures of surfactin which were shown the short half-life, rapid clearance and poor bioavailability. The results of study should provide preliminary data of surfactin for further dose-finding studies and for the design of application forms. It is also be important to a context of the safety of surfactin.

Keywords

References

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