Toxicological Research

Korean Society of Toxicology & Korea Environmental Mutagen Society (한국독성학회)
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Protective Activity Against Oxidative Stress of Plants Indigenous to Korea

  • Jung Myung Sun (Department of Biochemistry, College of Medicine and Applied Radiological Science research Institute, Cheju National University) ;
  • Kang Kyoung Ah (Department of Biochemistry, College of Medicine and Applied Radiological Science research Institute, Cheju National University) ;
  • Zhang Rui (Department of Biochemistry, College of Medicine and Applied Radiological Science research Institute, Cheju National University) ;
  • Chae Sungwook (Department of Biochemistry, College of Medicine and Applied Radiological Science research Institute, Cheju National University) ;
  • Yoo Byoung-Sam (Cosmetic R&D Center, COSMAX Inc.,) ;
  • Yang Young Taek (Jeju-do Agricultural Research & Extension Services) ;
  • Lee Nam Ho (Department of Chemistry, College of Natural Science, Cheju National University) ;
  • Park Jae Woo (Department of Nuclear and Energy Engineering, Cheju National University) ;
  • Hyun Jin Won (Department of Biochemistry, College of Medicine and Applied Radiological Science research Institute, Cheju National University)
  • Published : 2005.12.01
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Abstract

We have screened the cytoprotective effect against $H_2O_2$ and $\gamma-ray$ radiation induced oxidative stress from 32 Korean plants. Betula ermani var.saitoana (caulis, leaves), Rosa wichuraiana (caulis), Sorbus commixta (caulis), Weigela florida (leaves), Cirsium rhinoceros (whole plant), and Viburnum erosum (caulis) were found to scavenge 1, 1-diphenyl-2-picrylhydrazyl (DPPH) radical and intracellular reactive oxygen species (ROS). As a result, extracts of six plants reduced cell death of Chinese hamster lung fibroblast (V79-4) cells induced by $H_2O_2$ treatment. In addition, these extracts protected cell death of V79-4 cells damaged by $\gamma-ray$ radiation. In addition, these extracts scavenged ROS generated by radiation. Taken together, the results suggest that Betula ermani var. saitoana, Rosa wichuraiana, Sorbus commixta, Weigela florida, Cirsium rhinoceros, and Vibumum erosum protect V79-4 cells against oxidative damage by radiation through scavenging ROS.

Keywords

References

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