Journal of Nutrition and Health

  • 제38권10호
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  • Pages.801-806
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  • 2005
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  • 2288-3886(pISSN)
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  • 2288-3959(eISSN)
한국영양학회 (The Korean Nutrition Society)
권호 표지

동과 분획물의 투여가 Streptozotocin 유발 당뇨 흰쥐의 혈당 및 혈장 지질수준에 미치는 영향

Effects of Fractions of Benincasa hispida on Plasma Levels of Glucose and Lipid in Streptozotocin Induced Diabetic Rats

  • 임숙자 (덕성여자대학교 자연과학대학 식품영양학과) ;
  • 이민환 (덕성여자대학교 자연과학대학 식품영양학과)
  • Lim, Sook-Ja (Department of Foods & Nutrition College of Natural Sciences, Duksung Women's University) ;
  • Lee, Min-Hwan (Department of Foods & Nutrition College of Natural Sciences, Duksung Women's University)
  • 발행 : 2005.12.01
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초록

본 연구는 streptozotocin으로 유발된 당뇨 흰쥐에게 동과에서 추출한 각 용매분획물을 14일간 경구투여한 후 혈당과 지질함량을 분석하였으며 다음과 같은 결론을 얻었다. 당뇨대조군과 비교시 실험 14일 후 당뇨실험군에서 체중감소가 낮아졌으며, 실험 10일째부터는 당뇨실험군에서 혈당 수준이 당뇨대조군보다 감소하는 경향을 보이었다. 특히 $CHCl_3$분획물 투여군과 $H_2O$분획물 투여군은 14일째에 유의적으로 낮은 수준을 나타내었다. 당뇨실험군은 혈장 유리지방산 수준에서도 당뇨대조군에 비해 낮은 수준이었으며 $CHCl_{3}$분획물 투여군은 혈장 중성지방 수준에서도 낮게 나타났으나 유의적인 차이는 보이지 않았다. ALT와 AST 활성도는 당뇨대조군에 비해 $H_2O$분획물 투여군에서 유의적으로 낮게 나타났다. 결론적으로 당뇨 유발 흰쥐에게 $CHCl_3$분획물의 투여가 실험적 당뇨에 대하여 체중의 감소를 둔화시키며 특히 혈장 중 포도당의 함량을 유의성있게 감소시키는 것으로 보아 당뇨병에 대한 개선효과가 있다고 사료된다.

This study was designed to examine the effects of fractions of ethanol extract of Benincasa hispida (wax gourd) on plasma glucose and lipid levels in streptozotocin (STZ) induced diabolic rats. sprague-Dawley rats were induced diabetes mellitus by STZ injection (45 mg/kg) into the tail vein and were divided into 5 groups: normal, STZ-control, three experimental diabetic groups. fractions of ethanol extract of Benincasa hispida were administered orally into the diabetic rats for 14 days. The food intake and body weight were monitored and plasma levels of glucose, cholesterol, HDL-cholesterol, triglyceride (TG) , free fatty acid (FFA) , and aminotransferase activity were analyzed. A significant lowering effects of plasma glucose levels were observed in the chloroform fraction and $H_2O$ fraction group compared to STZ-control group at 14 days. Administrations of each of the three fractions decreased plasma TG and FFA levels in diabetic rats. Activity of alanine aminotransferase (ALT) in $CHCl_3$ fraction and $H_2O$ fraction groups and aspartate aminotransferase (AST) in $H_2O$ fraction group significantly lower than STZ-control group. The results show that $CHCl_3$ fraction of Benincasa hispida could be effective to control the STZ-induced diabetic rats. (Korean J Nutrition 38(10): 801$\sim$806,2005)

키워드

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