Biomolecules & Therapeutics

The Korean Society of Applied Pharmacology (한국응용약물학회)
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Stem Cell Biotechnology for Cell Therapy

  • LEE Dong-Ree (Department of Life Sciences, University of Seoul) ;
  • KIM Ha Won (Department of Life Sciences, University of Seoul)
  • Published : 2005.12.01
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Abstract

Cell therapy (CT) is a group of techniques to treat human disorders by transplantation of cells which have been processed and propagated independent of the living body. Blood transfusion and bone marrow transplant have been the primary examples of cell therapy. With introduction of stem cell (SC) technologies, however, CT is perceived as the next generation of biologies to treat human diseases such as cancer, neurological diseases, and heart disease. Despite potential of cell therapy, insufficient guidelines have been implemented concerning safety test and regulation of cell therapy. This review addresses the safety issues to be resolved for the cell therapy, especially SC therapy, to be successfully utilized for clinical practice. Adequate donor cell screening must preceed to ensure safety in cell therapy. In terms of SC culture, controlled, standardized practices and procedures should be established. Further molecular studies should be done on SC development and differentiation to enhance safety level in cell therapy. Finally, animal model must be further installed to evaluate toxicity, new concepts, and proliferative potential of SC including alternative feeder layer of animal cells.

Keywords

References

  1. Armson, B. A (2005). Maternal/fetal medicine committee, society of obstetricians and gynaecologists of Canada. Umbilical cord blood banking: implications for perinatal care providers. J. Obstet Gynaecol. Can. 27, 263-290
  2. Aslam, I. , Fishel, S., Moore, H., Dowell, K. and Thornton, S. (2000). Fertility preservation of boys undergoing anti-cancer therapy: a review of the existing situation and prospects for the future. Hum. Reprod. 15, 2154-2159 https://doi.org/10.1093/humrep/15.10.2154
  3. Bahadur, G. Ethics of testicular stem cell medicine. (2004). Hum Reprod., 19, 2702-2710 https://doi.org/10.1093/humrep/deh538
  4. Caplan, A. I. and Bruder, S. (2001). Mesenchymal stem cells: building blocks for molecular medicine in the 21st century. Trends Mo.l Mol. 7, 259-264 https://doi.org/10.1016/S1471-4914(01)02016-0
  5. Caulfield, T., Knowles, L. and Meslin, E. M. (2004). Law and policy in the era of reproductive genetics. J. Med. Ethics 30, 414-417 https://doi.org/10.1136/jme.2002.001370
  6. Cogle, C. R., Guthrie, S. M., Sanders, R. C., Allen, W. L., Scott, E. W., and Petersen, B. E. (2003). An overview of stem cell research and regulatory issues. Mayo Clin. Proc. 78, 993-1003 https://doi.org/10.4065/78.8.993
  7. Deisseroth, A. B., Holmes, F, Hortobagyi, G. and Champlin, R. (1996). Use of safety-modified retroviruses to introduce chemotherapy resistance sequences into normal hematopoietic cells for chemoprotection during the therapy of breast cancer: a pilot trial. Hum. Gene Ther. 7, 401-16 https://doi.org/10.1089/hum.1996.7.3-401
  8. Hintzen, R. Q. (2002). Stem cell transplantation in multiple sclerosis: multiple choices and multiple challenges. Mult. Scler. 8, 155-160 https://doi.org/10.1191/1352458502ms789oa
  9. Kline, R. M., and Bertolone, S. J. (1998). Umbilical cord blood transplantation: providing a donor for everyone needing a bone marrow transplant? South. Med. J. 91, 821-828 https://doi.org/10.1097/00007611-199809000-00004
  10. Parens, E. and Knowles, L. P. (2003). Reprogenetics and public policy. Reflections and recommendation. Hastings Cent. Rep. 33, 1-24
  11. Prosper, F., Herreros, J. and Barba, J. (2004). Future perspectives in the treatment of heart failure: from cell transplantation to cardiac regeneration. Rev. Esp. Cardiol. 57, 981-988
  12. Romano, G. (2004). Stem cell transplantation therapy: controversy over ethical issues and clinical relevance. Drug News Perspect. 17,637-645 https://doi.org/10.1358/dnp.2004.17.10.873915
  13. Schatten, G. P. (2002). Safeguarding ART. Nat. Cell Biol. 4 Suppl, 19-22 https://doi.org/10.1038/ncb-nm-fertilityS19
  14. Schwartz, R. S. and Curfman, G. D. (2002). Can the heart repair itself? N. Engl. J. Med. 346, 2-4 https://doi.org/10.1056/NEJM200201033460102
  15. Teshima, A. and Harada, M. (1997). Mobilization of peripheral blood progenitor cells for allogeneic transplantation. Cytokines Cell Mol. Ther. 3, 101-114
  16. Testa, G. and Harris, J. (2005). Ethics and synthetic gametes. Bioethics 19, 146-166 https://doi.org/10.1111/j.1467-8519.2005.00431.x
  17. Yim, R. (2005). Administrative and research policies required to bring cellular therapies from the research laboratory to the patient's bedside. Transfusion 45, 144S-158 https://doi.org/10.1111/j.1537-2995.2005.00616.x