The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Ampelopsis Radix Extracts on Tumor Immunity

  • Park Seung Man (Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Cho Jung Hyo (Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Son Chang Gue (Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Shin Jang Wo (Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Lee Yeon Weo (Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Yoo Hwa Seung (Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Lee Nam Heon (Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Yun Dam Hee (Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University) ;
  • Ahn Sang Woo (Korean Institute of Oriental Medicine) ;
  • Cho Chong Kwan (Department of East-West Cancer Center, Dunsan Oriental Hospital of Daejeon University)
  • Published : 2005.12.01
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Abstract

Objectives: This experimental study was carried out to evaluate the immune modulating and anti-tumor activity of Ampelopsis Radix extracts (ARE). Materials and Methods: To elucidate the effects of ARE on the macrophage and NK cell activity, we analyzed NO production, NK cytotoxicity and gene expressions of cytokine related with macrophage and NK cell activity. Results: ARE activated and promoted macrophages to product NO in part. And, ARE has significant properties to activate macrophages and NK cells by promoting related cytokines like IL-1, IL-12, IFN-$\gamma$, iNOS and TNF-$\alpha$ gene expressions. We also observed that ARE promoted protein expression of IFN-$\gamma$, and TNF-$\alpha$ in mice splenocytes. Conclusions: ARE is an effective herbal drug for immune modulating and anti-cancer by promoting activity of macrophages and NK cells.

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