Acknowledgement
Supported by : NIH
References
- Aggarwal, S., Ghilardi, N., Xie, M. H., De Sauvage, F. J., and Gurney, A. L. (2003) Interleukin-23 promotes a distinct CD4 T cell activation state characterized by the production of interleukin- 17. J. Biol. Chem. 278, 1910-1914 https://doi.org/10.1074/jbc.M207577200
-
Albanesi, C., Cavani, A., and Girolomoni, G. (1999) IL-17 is produced by nickel-specific T lymphocytes and regulates ICAM-1 expression and chemokine production in human keratinocytes: synergistic or antagonistic effects with IFN-
${\gamma}$ and TNF-${\alpha}$ . J. Immunol. 162, 494-502 - Bettelli, E. and Kuchroo, V. K. (2005) IL-12- and IL-23- induced T helper cell subsets: birds of the same feather flock together. J. Exp. Med. 201, 169-171 https://doi.org/10.1084/jem.20042279
- Dong, C. and Nurieva, R. I. (2003) Regulation of immune and autoimmune responses by ICOS. J. Autoimmunity 21, 255-260 https://doi.org/10.1016/S0896-8411(03)00119-7
- Fossiez, F., Djossou, O., Chomarat, P., Flores-Romo, L., Ait- Yahia, S., et al. (1996) T cell interleukin-17 induces stromal cells to produce proinflammatory and hematopoietic cytokines. J. Exp. Med. 183, 2593-2603 https://doi.org/10.1084/jem.183.6.2593
- Frucht, D. M. (2002) IL-23: a cytokine that acts on memory T cells. Sci. STKE 2002, E1
- Gaffen, S. and Liu, K. D. (2004) Overview of interleukin-2 function, production and clinical applications. Cytokine 28, 109-123 https://doi.org/10.1016/j.cyto.2004.06.010
- Gaffen, S. L. (2004) Interleukin-17: a unique inflammatory cytokine with roles in bone biology and arthritis. Arth. Res. Ther. 6, 240-247 https://doi.org/10.1186/ar1444
- Ghilardi, N., Kljavin, N., Chen, Q., Lucas, S., Gurney, A. L., et al. (2004) Compromised humoral and delayed-type hypersensitivity responses in IL-23-deficient mice. J. Immunol. 172, 2827-2833
- Happel, K. I., Zheng, M., Young, E., Quinton, L. J., Lockhart, E., et al. (2003) Cutting edge: roles of toll-like receptor 4 and IL-23 in IL-17 expression in response to Klebsiella pneumoniae infection. J. Immunol. 170, 4432-4436
- Hogan, P. G., Chen, L., Nardone, J., and Rao, A. (2003) Transcriptional regulation by calcium, calcineurin, and NFAT. Genes Dev. 17, 2205-2232 https://doi.org/10.1101/gad.1102703
- Hsieh, C. S., Macatonia, S. E., O'garra, A., and Murphy, K. M. (1995) T cell genetic background determines default T helper phenotype development in vitro. J. Exp. Med. 181, 713-721 https://doi.org/10.1084/jem.181.2.713
- Jain, J., Loh, C., and Rao, A. (1995) Transcriptional regulation of the IL-2 gene. Cur. Opin. Immunol. 7, 333-342 https://doi.org/10.1016/0952-7915(95)80107-3
- Kelly, M. N., Kolls, J. K., Happel, K., Schwartzman, J. D.,Schwarzenberger, P., et al. (2005) Interleukin-17/interleukin- 17 receptor-mediated signaling is important for generation of an optimal polymorphonuclear response against Toxoplasma gondii infection. Infect Immun. 73, 617-621 https://doi.org/10.1128/IAI.73.1.617-621.2005
- Kennedy, J., Rossi, D. L., Zurawski, S. M., Vega, F. Jr, Kastelein, R. A., et al. (1996) Mouse IL-17: a cytokine preferentially expressed by ab TCR + CD4-CD8-T cells. J. Interferon Cytokine Res. 16, 611-617 https://doi.org/10.1089/jir.1996.16.611
- Kolls, J. K. and Linden, A. (2004) Interleukin-17 family members and inflammation. Immunity 21, 467-476 https://doi.org/10.1016/j.immuni.2004.08.018
- Kostulas, N., Pelidou, S. H., Kivisakk, P., Kostulas, V., and Link, H. (1999) Increased IL-1beta, IL-8, and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study. Stroke 30, 2174-2179 https://doi.org/10.1161/01.STR.30.10.2174
- Langrish, C. L., McKenzie, B. S., Wilson, N. J., de Waal Malefyt, R., Kastelein, R. A., et al. (2004) IL-12 and IL-23: master regulators of innate and adaptive immunity. Immunol. Rev. 202, 96-105 https://doi.org/10.1111/j.0105-2896.2004.00214.x
- Langrish, C. L., Chen, Y., Blumenschein, W. M., Mattson, J., Basham, B., et al. (2005) IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201, 233-240 https://doi.org/10.1084/jem.20041257
- Linden, A. and Adachi, M. (2002) Neutrophilic airway inflammation and IL-17. Allergy 2002. 57, 769-775
- Liu, X., Lin, X., and Gaffen, S. L. (2004) Crucial role for nucelar factor of activated T cells (NFAT) in T cell receptormediated regulation of the human interleukin-17 gene. J. Biol. Chem. 279, 52762-52771 https://doi.org/10.1074/jbc.M405764200
- Matusevicius, D., Kivisakk, P., He, B., Kostulas, N., Ozenci V., et al. (1999) Interleukin-17 mRNA expression in blood and CSF mononuclear cells is augmented in multiple sclerosis. Mult. Scler. 5, 101-104
- Moseley, T. A., Haudenschild, D. R., Rose, L., and Reddi, A. H. (2003) Interleukin-17 family and IL-17 receptors. Cytokine Growth Factor Rev. 14, 155-174 https://doi.org/10.1016/S1359-6101(03)00002-9
- Nakae, S., Komiyama, Y., Nambu, A., Sudo, K., Iwase, M., et al. (2002) Antigen-specific T cell sensitization is impaired in IL-17-deficient mice, causing suppression of allergic cellular and humoral responses. Immunity 17, 375-387 https://doi.org/10.1016/S1074-7613(02)00391-6
- Nakae, S., Saijo, S., Horai, R., Sudo, K., Mori, S., et al. (2003) IL-17 production from activated T cells is required for the spontaneous development of destructive arthritis in mice deficient in IL-1 receptor antagonist. Proc. Natl. Acad. Sci. USA 100, 5986-5990
- Oppmann, B., Lesley, R., Blom, B., Timans, J. C., Xu, Y., et al. (2000) Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. Immunity 13, 715-725 https://doi.org/10.1016/S1074-7613(00)00070-4
- Rouvier, E., Luciani, M.-F., Mattei, M.-G., Denizot, F., and Golstein, P. (1993) CTLA-8, cloned from an activated T cell, bearing AU-rich messenger RNA instability sequences, and homologous to a herpesvirus saimiri gene. J. Immunol. 150, 5445-5456
- Ruddy, M. J., Shen, F., Smith, J., Sharma, A., and Gaffen, S. L. (2004) Interleukin-17 regulates expression of the CXC chemokine LIX/CXCL5 in osteoblasts: implications for inflammation and neutrophil recruitment. J. Leukoc. Biol. 76, 135-144 https://doi.org/10.1189/jlb.0204065
- Shen, F., Ruddy, M. J., Plamondon, P., and Gaffen, S. L. (2005) Cytokines link osteoblasts and inflammation: microarray analysis of interleukin-17- and TNF-alpha-induced genes in bone cells. J. Leukoc. Biol. 77, 388-399
- Shin, H. C., Benbernou, N., Esnault, S., and Guenounou, M. (1999) Expression of IL-17 in human memory CD45RO+ T lymphocytes and its regulation by protein kinase A pathway. Cytokine 11, 257-266 https://doi.org/10.1006/cyto.1998.0433
- Stark, M. A., Huo, Y., Burcin, T. L., Morris, M. A., Olson, T. S., et al. (2005) Phagocytosis of apoptotic neutrophils regulates granulopoiesis via IL-23 and IL-17. Immunity 22, 285-294 https://doi.org/10.1016/j.immuni.2005.01.011
- Tartour, E., Fossiez, F., Joyeux, I., Galinha, A., Gey, A., et al. (1999) Interleukin 17, a T-cell-derived cytokine, promotes tumorigenicity of human cervical tumors in nude mice. Cancer Res. 59, 3698-3704
- Teunissen, M. B., Koomen, C. W., De Waal Malefyt, R., Wierenga, E. A., and Bos, J. D. (1998) Interleukin-17 and interferon- g synergize in the enhancement of proinflammatory cytokine production by human keratinocytes. J. Invest. Dermatol. 111, 645-649 https://doi.org/10.1046/j.1523-1747.1998.00347.x
- Yao, Z., Fanslow, W. C., Seldin, M. F., Rousseau, A. M., Painter, S. L., et al. (1995a) Herpesvirus Saimiri encodes a new cytokine, IL-17, which binds to a novel cytokine receptor. Immunity 3, 811-821 https://doi.org/10.1016/1074-7613(95)90070-5
- Yao, Z., Painter, S. L., Fanslow, W. C., Ulrich, D., Macduff, B. M., et al. (1995b) Human IL-17: a novel cytokine derived from T cells. J. Immunol. 155, 5483-5486
- Ye, P., Garvey, P. B., Zhang, P., Nelson, S., Bagby, G., et al. (2001) Interleukin-17 and lung host defense against Klebsiella pneumoniae infection. Am. J. Respir. Cell Mol. Biol. 25, 335-340 https://doi.org/10.1165/ajrcmb.25.3.4424
- Zhou, L., Wang, J., Peng, S., Duan, J., Cai, X., et al. (1998) High-level expression of human interleukin-17 in the yeast Pichia pastoris. Biochem. Mol. Biol. Int. 46, 1109-1116
- Ziolkowska, M., Koc, A., Luszczykiewicz, G., Ksiezopolska- Pietrzak, K., Klimczak, E., et al. (2000) High levels of IL-17 in rheumatoid arthritis patients: IL-15 triggers in vitro IL-17 production via cyclosporin A-sensitive mechanism. J. Immunol. 164, 2832-2838