Clinical and Experimental Reproductive Medicine

The Korean Society for Reproductive Medicine (대한생식의학회)
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Cytogenetic Study in 535 Couples with Recurrent Spontaneous Abortions in Korea

한국에서 반복 자연유산을 하는 535쌍의 부부에 있어서의 세포 유전학적 연구

  • Hwang, Han Sung (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
  • Yang, Eun Suk (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
  • Hong, Won Ki (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University) ;
  • Kim, Mi Soon (The Genetic Laboratory of the Medical Research Center, College of Medicine, Yonsei University) ;
  • Yang, Young Ho (Department of Obstetrics and Gynecology, College of Medicine, Yonsei University)
  • 황한성 (연세대학교 의과대학 산부인과학교실) ;
  • 양은석 (연세대학교 의과대학 산부인과학교실) ;
  • 홍원기 (연세대학교 의과대학 산부인과학교실) ;
  • 김미순 (연세대학교 의과대학 임상의학 연구 센터 유전학 검사실) ;
  • 양영호 (연세대학교 의과대학 산부인과학교실)
  • Published : 2005.06.30
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Abstract

Objective: The purposes of this study were to investigate the types and the incidences of chromosomal abnormalities, and to provide an explanation for the genetic causations of recurrent spontaneous abortions in Korean population. Methods: Cytogenetic studies were carried out in 535 couples with at least two spontaneous first trimester abortions from January 1981 to December 2003. For karyotype analysis, we used modified Moorhead method by Giemsa staining and Giemsa-Trypsin-Giemsa banding Results: The overall incidence of chromosome abnormality was 32 out of 535 cases (5.98%). There were 25 cases (4.67%) of translocation and 7 cases (1.31%) of inversion. In translocation, 5 cases (0.93%) of Robertsonian translocation and 20 cases (3.74%) of reciprocal translocation were observed. In inversion, 6 cases (1.12%) of inversion of chromosome 9 and one case (0.19%) of inversion of chromosome 18 were found. Conclusion: In this study, overall chromosomal abnormality rate in couples with recurrent spontaneous abortions is much higher than that in the general population. So, chromosomal analysis should be offered for the prognostic information in genetic counseling such as prenatal diagnosis in couples with repetitive reproductive failure.

Keywords

References

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