Application of Pulsed Field Gradient Long-range COSY-NMR for the Assignment of Geminal Protons on Rigid System: supplemental method of NOE Experiment

NOE 실험의 대용으로 응용될 수 있는 PFG Long-range COSY NMR 실험

  • Lee, Sueg-Geun (Chemical Analysis Lab., Korea Research Institute of Chemical Technology)
  • Received : 2004.10.25
  • Accepted : 2004.11.12
  • Published : 2005.02.25

Abstract

Antiphase character of cross peaks in long-range COSY is modulated by changing the fixed delay time and used to assign diastereotopic methylene protons on rigid systems which could produce unpredictable NOE phenomena because of complicate coupling spins.

Keywords

References

  1. S. Sternhell, Quart. Rev., 23, 236(1969) https://doi.org/10.1039/qr9692300236
  2. M. Barfield and B. Chakrabarti, Chem. Rev., 69, 757(1969) https://doi.org/10.1021/cr60262a001
  3. T. Parella, Magn. Reson. Chem., 36, 467 (1998) and references cited therein https://doi.org/10.1002/(SICI)1097-458X(199807)36:7<467::AID-OMR325>3.0.CO;2-S
  4. J. R. Toleman, and J. H. Prestegard, Concepts Magn. Reson., 7, 247(1995) https://doi.org/10.1002/cmr.1820070402
  5. R. E. Hurd, In Encyclopedia of NMR; R. K. Harris and D. M. Grant, Eds; Wiley: Chichester, U.K., 1996; Vol. 3; p. 1990
  6. P. Barker and R. Freeman, J. Magn. Reson., 64, 334(1985)
  7. S.-G. Lee, Bull. Korean Chem. Soc., 22, 789 (2001) https://doi.org/10.1007/BF02705800
  8. A. Bax, Two-Dimensional Nuclear Magnetic Resonance in Liquids; Delft University Press: Dordrecht, Holland, 1985
  9. D. Neuhaus and M. P. Williamson, The Nuclear Overhauser Effect in Structural and Conformational Analysis, VCH Publisher, New York, 1989
  10. A. Y. Badjah, B. Y. Meklati, H. Waton and Q. T. Pham, Magn. Reson. Chem., 30, 807(1992) and references cited therein https://doi.org/10.1002/mrc.1260300902
  11. S.-G. Lee, Magn. Reson. Chem., 40, 311(2002) and references cited therein https://doi.org/10.1002/mrc.972
  12. Bruker reported that 10 % gradient strength for a standard 5 mm Willmad sample tube trans- lated into a gradient strength of 5.14 Gs/cm
  13. K.-Y. Kim and S.-G. Lee, Magn. Reson. Chem.,35, 451(1997) https://doi.org/10.1002/(SICI)1097-458X(199707)35:7<451::AID-OMR113>3.0.CO;2-R
  14. This kind of intensity modulation was also observed in the long-range CH-correlation spectrum. A. S. Zektzer, B. K. John and G. E. Martin, Magn. Reson. Chem., 25, 752(1987) https://doi.org/10.1002/mrc.1260250903
  15. Technical Information Bulletin No. AL-199, Aldrich, USA