Asian-Australasian Journal of Animal Sciences

  • 제18권1호
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  • Pages.3-7
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  • 2005
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  • 1011-2367(pISSN)
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  • 1976-5517(eISSN)
아세아태평양축산학회 (Asian Australasian Association of Animal Production Societies)
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Identification of Novel SNPs in Bovine Insulin-like Growth Factor Binding Protein-3 (IGFBP3) Gene

  • Kim, J.Y. (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Yoon, D.H. (National Livestock Research Institute, RDA) ;
  • Park, B.L. (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Kim, L.H. (Department of Genetic Epidemiology, SNP Genetics, Inc.) ;
  • Na, K.J. (National Livestock Research Institute, RDA) ;
  • Choi, J.G. (National Livestock Research Institute, RDA) ;
  • Cho, C.Y. (National Livestock Research Institute, RDA) ;
  • Lee, H.K. (Department of Biotechnology, Hankyong National University) ;
  • Chung, E.R. (Department of Biotechnology, Sangi University) ;
  • Sang, B.C. (Department of Dairy Science, Graduate School, Chungnam National University) ;
  • Cheong, I.J. (National Livestock Research Institute, RDA) ;
  • Oh, S.J. (National Livestock Research Institute, RDA) ;
  • Shin, Hyoung Doo (Department of Genetic Epidemiology, SNP Genetics, Inc.)
  • 투고 : 2003.09.08
  • 심사 : 2004.02.09
  • 발행 : 2005.01.01
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초록

The insulin-like growth factors (IGFs), their receptors, and their binding proteins play key roles in regulating cell proliferation and apoptosis. Insulin-like growth factor binding protein-3 (IGFBP3, OMIM #146732) is one of the proteins that bind to the IGFs. IGFBP3 is a modulator of IGF bioactivity, and direct growth inhibitor in the extravascular tissue compartment. We identified twenty-two novel single nucleotide polymorphisms (SNPs) in IGFBP3 gene in Korean cattle (Hanwoo, Bos taurus coreanae) by direct sequencing of full gene including -1,500 bp promoter region. Among the identified SNPs, five common SNPs were screened in 650 Korean cattle; one SNP in promoter (IGFBP3 G-854C), one in 5'UTR region (IGFBP3 G-100A), two in intron 1 (IGFBP3 G+421T, IGFBP3 T+1636A), and one in intron 2 (IGFBP3 C+3863A). The frequencies of each SNP were 0.357 (IGFBP3 G-854C), 0.472 (IGFBP3 G-100A), 0.418 (IGFBP3 G+421T), 0.363 (IGFBP3 T+1636A) and 0.226 (IGFBP3 C+3863A), respectively. Haplotypes and their frequencies were estimated by EM algorithm. Six haplotypes were constructed with five SNPs and linkage disequilibrium coefficients (|D'|) between SNP pairs were also calculated. The information on SNPs and haplotypes in IGFBP3 gene could be useful for genetic studies of this gene.

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참고문헌

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피인용 문헌

  1. Identification of Functional and In silico Positional Differentially Expressed Genes in the Livers of High- and Low-marbled Hanwoo Steers vol.20, pp.9, 2005, https://doi.org/10.5713/ajas.2007.1334
  2. DdeI Polymorphism in Coding Region of Goat POU1F1 Gene and Its Association with Production Traits vol.20, pp.9, 2007, https://doi.org/10.5713/ajas.2007.1342
  3. Association Analysis between Insulin-like Growth Factor Binding Protein 3 (IGFBP3) Polymorphisms and Carcass Traits in Cattle vol.21, pp.3, 2005, https://doi.org/10.5713/ajas.2008.60476
  4. Single nucleotide polymorphism in Egyptian cattle insulin-like growth factor binding protein-3 gene vol.12, pp.2, 2014, https://doi.org/10.1016/j.jgeb.2014.07.001