Clinical and Experimental Pediatrics

대한소아청소년과학회 (The Korean Pediatric Society)
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2000년부터 2002년까지 부산지역에서 유행한 인플루엔자의 원인균 동정 및 유행시기

Retrospective Study for the Isolation of Influenza Virus and Prevalence Period in Busan from 2000 to 2002

  • 투고 : 2004.09.07
  • 심사 : 2004.10.12
  • 발행 : 2005.03.15
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초록

목 적 : 인플루엔자는 주기적인 유행을 통해 높은 사망률과 유병률을 초래하며 인플루엔자 유행 시에 지역사회에서 폐렴의 증가, 인플루엔자 유사질환에 의한 입원의 증가, 사망률의 증가등을 통해 나타나게 된다. 이에 저자들은 최근 부산지역에서 유행한 인플루엔자 바이러스를 동정하고 유행 시기를 알아보고자 한다. 방 법 : 2000년부터 2002년까지 최근 3년간 성분도병원 소아과를 비롯한 부산광역시의 10개 감시지정병원과 부산광역시의 16개 보건소의 외래로 내원하였거나 입원하였던 환자 중 임상적으로 인플루엔자가 의심되는 환자들에게서 채취한 인후 도찰물, 콧물 등의 가검물을 배양하여 인플루엔자의 유형과 성별, 연령별 발생분포, 유행 시기 등을 분석하였다. 결 과 : 1) 3년간 총 209주의 인플루엔자 바이러스가 분리되었다. 2000년에는 A/sydney/05/97(H3N2)-like, A/Beijing/262/95(H1N1)-like와 B/Harbin/07/94-like이었으며, 2001년에 분리된 바이러스는 A/Panama/2007/99(H3N2)-like와 A/Newcaledonia/20/99(H1N1)-like이었고, 2002년도에는 A/Panama/2007/99(H3N2)-like, A/Newcaledonia/20/99(H1N1)-like와 B/Beijing/243/97, B/Honkong/22/2001, B/Sichuam/379/99이었다. 분리된 바이러스의 성별 발생 분포는 2000년 남성 환자 14명(32.56%), 여성 환자 25명(67.44%), 2001년 남성 환자 23명(41.07%), 여성환자 33명(58.93%), 2002년 남성 환자 57명(50%), 여성 환자 57명(50%)이 발생하였다. 2) 연령별 발생 분포는 2000년에는 0-10세 사이에서 48.84%로 대부분을 차지하였으나 2001년에는 11-20세 사이에서 33.93%로 비교적 높은 비율을 보였고, 2002년에는 10세 이하가 64.91%로 대부분을 차지하였다. 3) 월별 발생 분포는 2000년에는 1월에 한 차례 높았다가 다시 4월에 다소 높은 발생을 보였으며 6월까지 낮은 비율이지만 다양한 바이러스가 출현하였다. 반면 2001년에는 2월과 3월에 집중적으로 발생하였다. 그리고 2002년에는 3월과 11월에 두 번이나 높은 발생을 나타내었다. 결 론 : 인플루엔자 바이러스는 잦은 항원변이를 보이고, 늦가을에서 초봄까지 유행하며, 특히 10세 이하의 소아에서 높은 이환율을 보이므로 각별한 예방대책이 강구되어야 하겠다.

Purpose : During epidemics, influenza induces a high mortality and morbidity, and when influenza is prevalent, it is revealed by increased pneumonia, hospitalization due to influenza-like illness, and mortality in community. We aimed at the isolation of influenza virus and prevalence period in Busan from 2000 to 2002. Methods : For 3 years from 2000 to 2002, we analyzed the patterns of influenza virus, the occurrence distribution of influenza by age and sex and the prevalence period after cultivating the examined materials from throat smears and snivel, collected from patients in St. Benedict Hospital Pediatrics Department, from 10 monitoring hospitals, and from 16 public health centers. Results : For three years, a total of 209 strains of influenza virus were isolated. In 2000, there were A/sydney/05/97(H3N2)-like, A/Beijing/262/95(H1N1)-like and B/Harbin/07/94-like. In 2001, there were A/Panama/2007/99(H3N2)-like and A/Newcaledonia/20/99(H1N1)-like. In 2002, there were A/Panama/2007/99(H3N2)-like, A/Newcaledonia/20/99(H1N1)-like, B/Beijing/243/97, B/Honkong/22/2001 and B/Sichuam/379/99. The occurrence distribution by sexes were 14 males and 25 females in 2000, 23 males and 33 females in 2001, 57 males and 57 females in 2002. As for the occurrence distribution by ages, 0-10 years made up 48.4 percent in 2000, 11-20 years 33.93 percent in 2001, and below 10 years was 64.91 percent in 2002. As for the occurrence distribution by month, the rate was once high in January and somewhat high in April and by June, when there happened to be various viruses, though there was a low rate in 2000. On the other hand, the virus was concentrated in February and March in 2001. And in 2002, it happened high twice, in March and November. Conclusion : Influenza virus revealed frequent antigenic changes and infect children, especially those below 10 years of age from late fall to early spring. So we should consider appropriate prevention in children.

키워드

참고문헌

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