Journal of Applied Biological Chemistry

The Korean Society for Applied Biological Chemistry (한국응용생명화학회)
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5-(Hydroxymethyl)-2-furfuraldehyde, Anticonvulsant Furan from the Arils of Euphoria longana L.

  • Kim, Dong-Hyun (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University) ;
  • Kim, Dae-Won (Department of Genetic Engineering, Division of Life Science, Hallym University) ;
  • Choi, Soo-Young (Department of Genetic Engineering, Division of Life Science, Hallym University) ;
  • Park, Chang-Ho (College of Environment & Applied Chemistry, Kyung Hee University) ;
  • Baek, Nam-In (Graduate School of Biotechnology & Plant Metabolism Research Center, KyungHee University)
  • Published : 2005.03.31
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Abstract

Arils of Euporia longana L. was extracted with 80% aqueous MeOH and partitioned successively with EtOAc, n-BuOH and $H_2O$. From the n-BuOH fraction, furan compound was isolated through silica gel column chromatography. The results of physico-chemical data including NMR, MS and IR revealed the compound to be 5-(hydroxymethyl)-2-furfuraldehyde. This compound stimulated GDH I activity by $19.2{\pm}0.6$, $41.2{\pm}0.9$, $68.4{\pm}1.1$, $80.3{\pm}0.9$ and $85.9{\pm}1.6%$ at in vitro concentrations of 0.005, 0.008, 0.02 and 0.03 %, respectively.

Keywords

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