Effects of Physical Training on Defence Mechanism of Aging and Memory Impairment of Senescence-accelerated SAMP8

운동이 SAMP8 마우스의 노화와 기억장애에 미치는 영향

  • Ku, Woo-Young (Department of Physical Education, Dong-Eui University) ;
  • Lee, Jong-Soo (Department of Food and Life Science, Pukyong University) ;
  • Kwak, Yi-Sub (Department of Leisure and Sport Science, Dong-Eui University)
  • 구우영 (동의대학교 체육학과) ;
  • 이종수 (부경대학교 식품영양학과) ;
  • 곽이섭 (동의대학교 레저스포츠학과)
  • Published : 2005.12.30

Abstract

Background: This study was designed to investigate the effect of exercise training on defense mechanism of chronic degenerative disease, aging, and memory impairments of senescence-accelerated mouse (SAM)P8 under the hypothesis that "Senile dementia may be prevented by regular exercises". Methods: To evaluate the effects of exercise training on the defense mechanism of aging and memory impairment, SAMP8 were divided into two groups, the control group and exercise training groups. the exercise training group were performed with low $(\dot{V}O_2max\;25{\sim}33%)$, middle ($\dot{V}O_2max$ 50%) and high $(\dot{V}O_2max\;66{\sim}75%)$ intensity exercise. All SAMP8 mice were fed experimental diet ad libitum until 4, 8 months, and dead period. Results: Median lifespan in middle exercise group resulted in a significantly increased (23.5% and 18.7%, respectively), whereas these lifespan in high exercise group resulted in an unexpectedly decreased (13.5% and 12.1%, respectively) compared with control group. Body fat levels in 4 and 8 months of age were significantly decreased 43% to 51% in middle exercise group, whereas were remarkably deceased to 57% in high exercise group compared with control group. It is believed that extended median and maximum lifespan may be effected by calory restriction through the exercise training. Acetylcholine (ACh) levels were significantly increased 6.7% and 8.5% in middle and high exercise groups, and also choline acetyltransfease (ChAT) activities were significantly increased 10.3% and 11.9% in middle and high exercise groups. Conclusion: These results suggest that proper and regular exercises such as middle group ($\dot{V}O_2max$ 50%) may play an effective role in attenuating an oxygen radicals and may play an important role in improving a learning and memory impairments of senile dementia.

Keywords

References

  1. McCay CM, Crowell MF, Maynard LA: The effects of retarded growth upon length of life span and upon ultimate body size. J Nutr 71;255-263, 1935
  2. Harman D: Aging: a theory based on free radical and radiation chemistry. J Gerontol 11;298-300, 1956 https://doi.org/10.1093/geronj/11.3.298
  3. Yu BP: Aging and oxidative stress: modulation by dietary restriction. Free Rad Biol Med 21;651-668, 1996 https://doi.org/10.1016/0891-5849(96)00162-1
  4. Yu BP, Yang R: Critical evaluation of free radical theory of aging: a proposal of oxidative stress hypothesis. Ann N Y Acad Sci 786;1-11, 1996 https://doi.org/10.1111/j.1749-6632.1996.tb39047.x
  5. Holloszy JO, Schechtman KB: Interaction between exercise and food restriction: effects on longevity of male rats. J Appl Physiol 70;1529-1535, 1991 https://doi.org/10.1152/jappl.1991.70.4.1529
  6. Weinsier RL, Hunter GR, Zuckerman PA, Redden DT, Darnell BE, Larson DE, Newcomer BR, Goran MI: Energy expenditure and free-living physical activity in black and white women; comparison before and after weight loss. AM J Clin Nutr 71;1138-1146, 2000
  7. Wilson TM, Tanaka H: Meta-analysis of the age-associated decline in maximal aerobic capacity in men; relation to training status. AM J Physiol Heart Circ Physiol 278;H829-834, 2000 https://doi.org/10.1152/ajpheart.2000.278.3.H829
  8. Laurin D, Verreault R, Lindsay J, MacPherson K, Rockwood K: Physical activity and risk of cognitive impairment and dementia in elderly persons. Arch Neurol 58;498-504, 2001 https://doi.org/10.1001/archneur.58.3.498
  9. Schuit AJ, Feskens EJ, Launer LJ, Kromhout D: Physical activity and cognitive decline, the role of the apolipoprotein e4 allele. Med Sci Sports Exerc 33;772-777, 2001
  10. Bedford TG, Tipton CM, Wilson NC, Oppliger RA, Gisolfi CV: Maximum oxygen consumption of rats and its changes with various experimental procedures. J Appl Physiol 47;1278-1283, 1979
  11. Yagi H, Katoh S, Akiguchi I, Takeda T: Age-related deterioration of ability of acqusition in memory and learning in SAMP/8 as an animal model of disturbances in recent memory. Brain Research 474;86-93, 1988 https://doi.org/10.1016/0006-8993(88)90671-3
  12. Choi JH, Yu BP: The effect of food restriction on kideny membrane structures of aging rats. AGE 12;133-136, 1989 https://doi.org/10.1007/BF02432350
  13. Rudel LL, Morris MD: Determination of cholesterol using o-phthaldehyde. J Lipid Res 14;364-366, 1973
  14. Bocquene G, Galgani F: Acetylcholinesterase activity in the common prawn contaminated by carbaryl and phosalone: choice of a method for detection of effects. Ecotoxicol Environ Saf 22;337-344, 1991 https://doi.org/10.1016/0147-6513(91)90083-2
  15. Steel RGD, Torrie JH: Principles and procedures of statistics. McGrawhill, New York, 1960
  16. Singh VA: A current perspective on nutrition and exercise. J Nutr 122;760-765, 1992 https://doi.org/10.1093/jn/122.suppl_3.760
  17. Goodrick CL, Ingram DK, Reynolds MA, Freeman JR, Cider NL: Differential effects of intermittent feeding voluntary exercise on body weight and lifespan in adult rats. J Gerontol 38;36-45, 1983 https://doi.org/10.1093/geronj/38.1.36
  18. Flood JF, Moriey AT: Age-related changes in footshock avoidance acquisition and retention in senescence accelerated mouse (SAM). Neurobiol Aging 14;153-157, 1993 https://doi.org/10.1016/0197-4580(93)90091-O
  19. Choi JH, Kim DW: Effect of age and dietary restriction on lifespan and oxidative stress of SAMP8 mice with learning and memory impairments J Nutr Health Aging 4;182-186, 2000
  20. Mosher PE, Ferguson MA, Arnold RO: Lipid and lipoprotein changes in premenstrual women following step aerobic dance training. Int J Sports Med 26;669-674, 2005 https://doi.org/10.1055/s-2004-830437