Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Pharmacological Effects of Asaronaldehyde Isolated from Acorus gramineus Rhizome

  • Kim, Hyo-Gyung (Faculty of Applied Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University) ;
  • Jeon, Ju-Hyun (Faculty of Applied Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University) ;
  • Kim, Moo-Key (Faculty of Applied Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University) ;
  • Lee, Hoi-Seon (Faculty of Applied Biotechnology and Research Center for Industrial Development of Biofood Materials, College of Agriculture, Chonbuk National University)
  • Published : 2005.10.31
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Abstract

Antibacterial and antiplatelet activities of Acorus gramineus rhizome-derived asaronaldehyde and asaron were analyzed using platelet aggregometer and six human intestinal bacteria. Active constituent of A. gramineus rhizome was isolated and characterized as asaronaldehyde by spectral analyses. At 2 and 1 mg/disk, asaronaldehyde exhibited strong inhibition of Clostridium perfringens and C. difficile without adverse effects on growth of beneficial bacteria such as Bifidobacterium bifidum, Lactobacillus acidophilus, and L. casei. Asaron also revealed moderate growth inhibition against C. perfringens and C. difficile at 2 mg/disk, no growth-inhibiting activity was observed on B. bifidum, L. acidophilus, L. casei, and E. coli. At 50% inhibitory concentration ($IC_{50}$) value, asaronaldehyde was effective in inhibiting platelet aggregation induced by collagen ($IC_{50}$, $27.6\;{\mu}M$) and arachidonic acid ($IC_{50}$, $53.7\;{\mu}M$). These results suggest asaronaldehyde may be useful as lead compound for inhibiting platelet aggregation induced by collagen and arachidonic acid.

Keywords

References

  1. Int. J. Aromather. v.14 Research reports Harris, B. https://doi.org/10.1016/j.ijat.2003.12.006
  2. Pharmacology and applications of Chinese Materia Medica (2 Vol.) Chang, H.M.;But, P.P.H.
  3. J. Ethnopharmacol. v.28 Central nervous system studies on an ethanol extract of Acarus calamus rhizomes Vohora, S.B.;Shaukat, A.;Shah, S.A;Dandiya, P.C.
  4. Phytother. Res. v.9 Anthelmintic and pesticidal activity of Acarus gramineus (Araceae) is associated with phenylpropanoid asarones Perrett, S.;Whitfield, P.J. https://doi.org/10.1002/ptr.2650090604
  5. J. Stored Prod. Res. v.39 Insecticidal activity of asarones identified in Acarus gramineus rhizome against three coleopteran stored-product insects Park, C.;Kim, S.I.;Ahn, Y.J. https://doi.org/10.1016/S0022-474X(02)00027-9
  6. J. Agric. Food Chem. v.52 Antifungal activity of ${\beta}-asarone$ from rhizomes of Aacarus gramineus Lee, J.Y.;Lee, J.Y;Yun, B.S.;Hwang, B.K. https://doi.org/10.1021/jf035204o
  7. Phytomedicine v.11 Screening of Korean herbal medicines used to improve cognitive function for anti-cholinesterase activity Oh, M.H.;Houghton, P.J.;Whang, W.K.;Cho, J.H. https://doi.org/10.1016/j.phymed.2004.03.001
  8. Yao Hsueh Tung Pao. v.16 Survey on the content and composition of volatile oil in Acarus gramineus Soland from different growing areas Zhang, H.;Wang, J.;Doo-Yau, Y.;Li, S.;An, D.
  9. Life Sci. v.71 Protection of cultured rat cortical neurons from excitotoxicity by asarone, a major essential oil component in the rhizomes of Acarus gramineus Cho, J.;Kim, Y.H.;Kang, J.Y.;Yang, C.H.;Park, C.G. https://doi.org/10.1016/S0024-3205(02)01729-0
  10. Life Sci. v.75 Therapeutic effects of herbal extracts and constituents in animal models of psychiatric disorders Zhang, Z.J. https://doi.org/10.1016/j.lfs.2004.04.014
  11. Bio. Pharm. Bull. v.26 Inhibitory effects of the fragrance inhalation of essential oil from Acarus gramineus on central nervous system Koo, B.S.;Park, K.S.;Ha, J.H.;Park, J.H.;Lim, J.C.;Lee, D.U. https://doi.org/10.1248/bpb.26.978
  12. Acta Pharm. Sin. v.4 Spasmolytic effects of active principles of the essential oil of Acarus gramineus Liu, G.Q.;Sun, J.N.;He, Z.Z.;Jiang, Y.
  13. Biol. Pharm. Bull. v.17 Effects of DX9386, a traditional Chinese preparation, on passive and active avoidance performances in mice Nishiyama, N.;Zhou, Y.;Takashina, K.;Saito, H. https://doi.org/10.1248/bpb.17.1472
  14. Biol. Pharm. Bull. v.17 Improving effects of DX-9386, a traditional Chinese medicinal prescription, on thymectomyinduced impairment of learning behaviors in mice Zhang, Y.;Saito, H.;Nishiyama, N. https://doi.org/10.1248/bpb.17.1199
  15. Food. Sci. Biotechnol. v.13 Antiplatelet activity of gallic acid and methyl gallate Lim, M.Y.;Park, Y.H.;Son, D.J.;Kim, M.K.;Lee, H.S.
  16. The Encyclopedia of Wakan-Yaku (Traditional Sino-Japanese Medicines) with Color Pictures. Vol. 1 Namba, T.
  17. Food. Sci. Biotechnol. v.14 Growth-inhibiting effects of Juniperus virginiana leaf-extracted components toward human intestinal bacteria Kim, M.Y.;Kim, Y.M.;Lee, H.S.
  18. Can. J. Physiol. Pharm. v.74 The mode of rabbit platelet shape change and aggregation induced by theonezolide-A, a novel polyketide macrolide, isolated from the okinawan marine sponge theonella sp Rho, M.C.;Park, Y.H.;Saaki, S.;Ishibashi, M.;Kondo, K.;Kobayashi, J.;hizumi, Y. https://doi.org/10.1139/cjpp-74-2-193
  19. Food. Sci. Biotechnol. v.13 Growth promoting effects of various potato varieties and breeding clones on lactic acid bacteria Kim, Y.M.;Lim, M.Y.;Jeon, J.H.;Lim, H.T.;Lee, H.S.
  20. J. Microbial. Biotechnol. v.13 Inhibitory effects of quinizarin isolated from Cassia tara seeds against human intestinal bacteria and aflatoxin $B_1$ biotransformation Lee, H.S.
  21. Can. J. Physiol. Pharm. v.72 Role of platelets in thrombosis and hemostasis Packham, M.A. https://doi.org/10.1139/y94-043
  22. Food. Sci. Biotechnol. v.13 Antiplatelet activity of phenylpropanoids isolated from Eugenia caryophyllata leaf oil Cho, J.H.;Lee, C.H.;Son, D.J.;Park, Y.H.;Lee, H.S.