Food Science and Biotechnology

Korean Society of Food Science and Technology (한국식품과학회)
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Flavonoid Compounds from Viola hondoensis and Their Effect on Matrix Metalloproteinase-1 in Ultraviolet Irradiation of Cultured Human Skin Fibroblasts

  • Moon, Hyung-In (Department of Dermatology, Seoul National University College of Medicine, and Clinical research Institute, Seoul National University Hospital) ;
  • Lee, Joong-Ku (Korea Research Institute of Bioscience and Biotechnology) ;
  • Zee, Ok-Pyo (College of Pharmacy, Sung kyun Kwan University) ;
  • Chung, Jin-Ho (Department of Dermatology, Seoul National University College of Medicine, and Clinical research Institute, Seoul National University Hospital)
  • Published : 2005.02.28
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Abstract

Although many studies have been performed to elucidate the molecular consequences of ultraviolet irradiation, little is known about the effect of natural products. Ultraviolet irradiation is widely considered to be an environmental stress. Here we investigated the effect of 2',4',7-trihydroxyisoflavone on the regulation of MMP-1 and type 1 procollagen in Ultraviolet irradiation of cultured human dermal fibroblasts. Phytochemical investigation of the whole plants of Viola hondoensis led to the isolation of five flavonoids. The structures of these compounds were identified 2',4',5,7-tetrahydroxyisoflavone (1), 2',4',7-trihydroxyisoflavone (2), 4',7-dihydroxyflavone (3), isoorientin (4), and isovitexin (5) using spectroscopic analysis. Among these, 2',4',7-trihydroxyisoflavone reduced the expression of MMP-1 at the protein levels in a dose-dependent manner by ultraviolet irradiation. Taken together, our results suggest that 2',4',7-trihydroxyisoflavone an important role in the reduction of MMP-1 induction by ultraviolet irradiation.

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