YAKHAK HOEJI (약학회지)

The Pharmaceutical Society of Korea (대한약학회)
권호 표지

Effects of Herbal Extracts on Serum and Liver Lipid Levels in Chronic Ethanol Administered Rats

만성적인 에탄올 섭취 시 수종 천연 추출물 투여가 흰쥐의 혈청과 간의 지질 함량에 미치는 영향

  • Kim Mok Kyung (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University) ;
  • Lee Yong Hyuk (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University) ;
  • Hyun Sun Hee (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University) ;
  • Choung Se Young (Department of Hygienic Chemistry, College of Pharmacy, Kyung Hee University)
  • Published : 2005.12.01
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Abstract

This study had been done for the investigation of the effect of Vitis vinifera extract (VV), Schisandra chinensis extract (SC), Taraxacum officinale extract (TO), Gardeniajasminoides extract (GJ), Angelica acutiloba extract (AA) and Paeonia japonica extract (PJ) on fatty liver and hepatotoxicity which was induced by Lieber-DeCarli ethanol liquid diet. Male Sprague-Dawley rats were randomly divided into eight groups: ethanol diet (ED), normal diet (ND), ED+VV (100mg/kg), ED+SC, ED+TO, ED+GJ, ED+AA, and ED+PJ (300mg/kg/day). Rats fed liquid diets for 6 weeks showed remarkable increase in serum and hepatic lipids indicating the onset of alcoholic fatty liver. The increasing levels of GPT, ALP activities in serum were observed in the groups fed with alcohol-containing diets compared to those of the ND group. The VV, SC, TO, GJ, AA and PJ groups were decreased the levels of triglyceride, free fatty acid and total cholesterol in serum and liver and GPT, ALP activities in serum. Therefore, they can be utiliaed as a health functional food or new drug candidate for fatty liver and hepatotoxicity which was induced by chronic alcohol consumption.

Keywords

References

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