The Journal of Korean Medicine (대한한의학회지)

The Society of Korean Medicine (대한한의학회)
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Effects of Hyeolbuchukyeo-tang on Stress

혈부축어탕 스트레스에 미치는 영향

  • Choi You-Kyung (Dep. of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Park Chong-hyeong (Dep. of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Jun Chan-yong (Dep. of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Kim Dong-woo (Dep. of Internal Medicine, College of Oriental Medicine, Kyung-won University) ;
  • Hwang Gui-seo (Dep. Of Preventive Medicine, College of Oriental Medicine, Kyung-won Univesity)
  • 최유경 (경원대학교 한의과대학 내과학교실) ;
  • 박종형 (경원대학교 한의과대학 내과학교실) ;
  • 전찬용 (경원대학교 한의과대학 내과학교실) ;
  • 김동우 (경원대학교 한의과대학 내과학교실) ;
  • 황귀서 (경원대학교 한의과대학 예방의학교실)
  • Published : 2005.09.01
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Abstract

Backgrounds : Two stress pathways, the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system, regulate immune system responses through release of corticosteroids, norepinephrine and epinephrine. respectively. These neuromediators act on immune cells via specific receptors on their surface to modulate the production of key regulatory cytokines. Objectives : To evaluate the preventive effects of oriental medicine Hyeolbuchukyeo-tang (HC) on stress. Methods : Mice were divided into three groups: nounal group, control group under immobilization stress and HC group which received Hyeolbuchukyeo-tang (HC) under immobilization stress. following sacrifice, their splenocytes were isolated and splenocyte surface markers were determined. The brains were removed and mRNA determined. In vivo, we separated RNA Iron cultured macrophages (RAW264.7). Results : In our study, immune functions were decreased in stress due mainly to changes of various neuromediators, cytokines and macrophage activities, and the treatment of HC increased those expressions. Conclusions : In summary, the present study documents the anti-stress effects of HC through stress-immune regulation.

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